CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis

Claudio Tripodo, Andrea Di Bernardo, Maria Paola Ternullo, Carla Guarnotta, Rossana Porcasi, Sabrina Ingrao, Umberto Gianelli, Emanuela Boveri, Emilio Iannitto, Giovanni Franco, Ada Maria Florena

Research output: Contribution to journalArticle

Abstract

CD146+ bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment. In this study we used immunohistochemical analysis to investigate the contribution of CD146+ bone marrow osteoprogenitors to the stromal remodeling occurring in the different stages of primary myelofibrosis. We found that CD146+ cells sited at the abluminal side of the bone marrow vessels and branching among hematopoietic cells significantly increased in the advanced stages of primary myelofibrosis (p+ cell involvement in bone marrow stromal changes occurring in primary myelofibrosis are consistent with the capability of these cells to participate in fiber deposition, angiogenesis, and bone formation. They could also represent a rationale for new therapies targeting the bone marrow stroma in primary myelofibrosis.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalHaematologica
Volume94
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Bone marrow osteoprogenitors
  • Primary myelofibrosis

ASJC Scopus subject areas

  • Hematology

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    Tripodo, C., Di Bernardo, A., Ternullo, M. P., Guarnotta, C., Porcasi, R., Ingrao, S., Gianelli, U., Boveri, E., Iannitto, E., Franco, G., & Florena, A. M. (2009). CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis. Haematologica, 94(1), 127-130. https://doi.org/10.3324/haematol.13598