CD20 expression has no prognostic role in Philadelphia-negative B-precursor acute lymphoblastic leukemia: New insights from the molecular study of minimal residual disease

Francesco Mannelli, Giacomo Gianfaldoni, Tamara Intermesoli, Chiara Cattaneo, Erika Borlenghi, Sergio Cortelazzo, Irene Cavattoni, Enrico Maria Pogliani, Monica Fumagalli, Emanuele Angelucci, Claudio Romani, Fabio Ciceri, Consuelo Corti, Anna Scattolin, Agostino Cortelezzi, Daniele Mattei, Ernesta Audisio, Orietta Spinelli, Elena Oldani, Alberto BosiAlessandro Rambaldi, Renato Bassan

Research output: Contribution to journalArticle

Abstract

The prognostic significance of CD20 expression in acute lymphoblastic leukemia has been investigated in children and adults but is still a subject of debate. The aim of our study was to correlate CD20 expression with clinical-biological characteristics and outcome in 172 Philadelphia chromosome negative patients prospectively treated in a multicenter trial introducing the molecular evaluation of minimal residual disease for therapeutic purposes. We considered 20% as the threshold for CD20 positivity. Complete remission rate, minimal residual disease negativity rate at weeks 10, 16 and 22, and disease-free and overall survival were similar among CD20-positive and -negative patients, even considering minimal residual disease results and related therapeutic choices. Our study failed to demonstrate any prognostic significance for CD20 expression in Philadelphia chromosome negative acute lymphoblastic leukemia. This conclusion is supported for the first time by a comparable minimal residual disease response rate among CD20-positive and -negative and positive patients. ClinicalTrials.gov ID, NCT00358072.

Original languageEnglish
Pages (from-to)568-571
Number of pages4
JournalHaematologica
Volume97
Issue number4
DOIs
Publication statusPublished - Apr 1 2012

Keywords

  • BCP-ALL
  • CD20
  • Minimal residual disease
  • Molecular
  • Philadelphia negative

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Mannelli, F., Gianfaldoni, G., Intermesoli, T., Cattaneo, C., Borlenghi, E., Cortelazzo, S., Cavattoni, I., Pogliani, E. M., Fumagalli, M., Angelucci, E., Romani, C., Ciceri, F., Corti, C., Scattolin, A., Cortelezzi, A., Mattei, D., Audisio, E., Spinelli, O., Oldani, E., ... Bassan, R. (2012). CD20 expression has no prognostic role in Philadelphia-negative B-precursor acute lymphoblastic leukemia: New insights from the molecular study of minimal residual disease. Haematologica, 97(4), 568-571. https://doi.org/10.3324/haematol.2011.054064