CD209 promoter polymorphisms associate with HCV infection and pegylated-interferon plus ribavirin treatment response

Luisa Zupin, Vania Polesello, Giulia Alberi, Giulia Moratelli, Saveria Lory Crocè, Flora Masutti, Gabriele Pozzato, Sergio Crovella, Ludovica Segat

Research output: Contribution to journalArticle

Abstract

Hepatitis C is a severe liver disease caused by hepatitis C virus that could persist in the host causing progression towards chronic disease in about 80% of the cases. Pegylated-interferon plus ribavirin was the gold standard therapy, however treatment's response was quite variable among individuals and different host/viral factors may play a role in disease outcome.The cluster of differentiation 209 (CD209 antigen) is a component of the innate immune system able to recognize HCV and consequently activating the immune response.We enrolled 203 Italian HCV infected patients and 220 healthy controls investigating if five promoter polymorphisms within CD209 gene (encoding for CD209 antigen) correlated with HCV infection susceptibility, spontaneous viral clearance and interferon treatment response.CD209 -939G > A and -871A > G polymorphisms associated with HCV infection susceptibility, while, CD209 -871A > G and -336A > G polymorphisms associated with response to treatment.In conclusion, CD209 polymorphisms could play a role in the susceptibility to HCV infection as well as interferon treatment response in our study population from North-East of Italy.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalMolecular Immunology
Volume76
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • CD209
  • HCV
  • Innate immunity
  • Interferon

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

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