TY - JOUR
T1 - CD30L up-regulates CD30 and IL-4 expression by T cells
AU - Rossi, Francesca Maria
AU - Degan, Massimo
AU - Mazzocut-Zecchin, Linda
AU - Di Francia, Raffaele
AU - Aldinucci, Donatella
AU - Pinto, Antonio
AU - Gattei, Valter
PY - 2001/11/23
Y1 - 2001/11/23
N2 - CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L+ neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.
AB - CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L+ neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.
KW - CD30
KW - CD30 ligand
KW - Interleukin-4
KW - T-helper 2 cells
UR - http://www.scopus.com/inward/record.url?scp=0035941130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035941130&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(01)03076-9
DO - 10.1016/S0014-5793(01)03076-9
M3 - Article
C2 - 11728464
AN - SCOPUS:0035941130
VL - 508
SP - 418
EP - 422
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 3
ER -