CD30L up-regulates CD30 and IL-4 expression by T cells

Francesca Maria Rossi; Massimo Degan; Linda Mazzocut-Zecchin; Raffaele Di Francia; Donatella Aldinucci; Antonio Pinto; Valter Gattei

doi:10.1016/S0014-5793(01)03076-9

CD30L up-regulates CD30 and IL-4 expression by T cells

Francesca Maria Rossi, Massimo Degan, Linda Mazzocut-Zecchin, Raffaele Di Francia, Donatella Aldinucci, Antonio Pinto, Valter Gattei

Research output: Contribution to journal › Article

Abstract

CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L⁺ neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.

Original language	English
Pages (from-to)	418-422
Number of pages	5
Journal	FEBS Letters
Volume	508
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(01)03076-9
Publication status	Published - Nov 23 2001

Keywords

CD30
CD30 ligand
Interleukin-4
T-helper 2 cells

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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Rossi, F. M., Degan, M., Mazzocut-Zecchin, L., Di Francia, R., Aldinucci, D., Pinto, A., & Gattei, V. (2001). CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Letters, 508(3), 418-422. https://doi.org/10.1016/S0014-5793(01)03076-9

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title = "CD30L up-regulates CD30 and IL-4 expression by T cells",

abstract = "CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L+ neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.",

keywords = "CD30, CD30 ligand, Interleukin-4, T-helper 2 cells",

author = "Rossi, {Francesca Maria} and Massimo Degan and Linda Mazzocut-Zecchin and {Di Francia}, Raffaele and Donatella Aldinucci and Antonio Pinto and Valter Gattei",

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T1 - CD30L up-regulates CD30 and IL-4 expression by T cells

AU - Rossi, Francesca Maria

AU - Degan, Massimo

AU - Mazzocut-Zecchin, Linda

AU - Di Francia, Raffaele

AU - Aldinucci, Donatella

AU - Pinto, Antonio

AU - Gattei, Valter

PY - 2001/11/23

Y1 - 2001/11/23

N2 - CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L+ neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.

AB - CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L+ neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.

KW - CD30

KW - CD30 ligand

KW - Interleukin-4

KW - T-helper 2 cells

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