CD30L up-regulates CD30 and IL-4 expression by T cells

Francesca Maria Rossi, Massimo Degan, Linda Mazzocut-Zecchin, Raffaele Di Francia, Donatella Aldinucci, Antonio Pinto, Valter Gattei

Research output: Contribution to journalArticle

Abstract

CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L+ neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalFEBS Letters
Volume508
Issue number3
DOIs
Publication statusPublished - Nov 23 2001

Keywords

  • CD30
  • CD30 ligand
  • Interleukin-4
  • T-helper 2 cells

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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