CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology

Elizabeth M. Bradshaw; Lori B. Chibnik; Brendan T. Keenan; Linda Ottoboni; Towfique Raj; Anna Tang; Laura L. Rosenkrantz; Selina Imboywa; Michelle Lee; Alina Von Korff; Martha C. Morris; Denis A. Evans; Keith Johnson; Reisa A. Sperling; Julie A. Schneider; David A. Bennett; Philip L. De Jager

doi:10.1038/nn.3435

CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology

Elizabeth M. Bradshaw, Lori B. Chibnik, Brendan T. Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L. Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C. Morris, Denis A. Evans, Keith Johnson, Reisa A. Sperling, Julie A. Schneider, David A. Bennett, Philip L. De Jager

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444C risk allele was associated with greater cell surface expression of CD33 in the monocytes (t₅₀ = 10.06, P _joint = 1.3 × 10^-13) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

Original language	English
Pages (from-to)	848-850
Number of pages	3
Journal	Nature Neuroscience
Volume	16
Issue number	7
DOIs	https://doi.org/10.1038/nn.3435
Publication status	Published - 2013

ASJC Scopus subject areas

Neuroscience(all)
Medicine(all)

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10.1038/nn.3435

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Bradshaw, E. M., Chibnik, L. B., Keenan, B. T., Ottoboni, L., Raj, T., Tang, A., Rosenkrantz, L. L., Imboywa, S., Lee, M., Von Korff, A., Morris, M. C., Evans, D. A., Johnson, K., Sperling, R. A., Schneider, J. A., Bennett, D. A., & De Jager, P. L. (2013). CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology. Nature Neuroscience, 16(7), 848-850. https://doi.org/10.1038/nn.3435

CD33 Alzheimer's disease locus : Altered monocyte function and amyloid biology. / Bradshaw, Elizabeth M.; Chibnik, Lori B.; Keenan, Brendan T.; Ottoboni, Linda; Raj, Towfique; Tang, Anna; Rosenkrantz, Laura L.; Imboywa, Selina; Lee, Michelle; Von Korff, Alina; Morris, Martha C.; Evans, Denis A.; Johnson, Keith; Sperling, Reisa A.; Schneider, Julie A.; Bennett, David A.; De Jager, Philip L.

In: Nature Neuroscience, Vol. 16, No. 7, 2013, p. 848-850.

Research output: Contribution to journal › Article › peer-review

Bradshaw, EM, Chibnik, LB, Keenan, BT, Ottoboni, L, Raj, T, Tang, A, Rosenkrantz, LL, Imboywa, S, Lee, M, Von Korff, A, Morris, MC, Evans, DA, Johnson, K, Sperling, RA, Schneider, JA, Bennett, DA & De Jager, PL 2013, 'CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology', Nature Neuroscience, vol. 16, no. 7, pp. 848-850. https://doi.org/10.1038/nn.3435

Bradshaw, Elizabeth M. ; Chibnik, Lori B. ; Keenan, Brendan T. ; Ottoboni, Linda ; Raj, Towfique ; Tang, Anna ; Rosenkrantz, Laura L. ; Imboywa, Selina ; Lee, Michelle ; Von Korff, Alina ; Morris, Martha C. ; Evans, Denis A. ; Johnson, Keith ; Sperling, Reisa A. ; Schneider, Julie A. ; Bennett, David A. ; De Jager, Philip L. / CD33 Alzheimer's disease locus : Altered monocyte function and amyloid biology. In: Nature Neuroscience. 2013 ; Vol. 16, No. 7. pp. 848-850.

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abstract = "In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444C risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P joint = 1.3 × 10-13) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.",

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CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology

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