CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology

Elizabeth M. Bradshaw, Lori B. Chibnik, Brendan T. Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L. Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C. Morris, Denis A. Evans, Keith Johnson, Reisa A. Sperling, Julie A. Schneider, David A. Bennett, Philip L. De Jager

Research output: Contribution to journalArticlepeer-review


In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444C risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P joint = 1.3 × 10-13) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

Original languageEnglish
Pages (from-to)848-850
Number of pages3
JournalNature Neuroscience
Issue number7
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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