Abstract
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444C risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P joint = 1.3 × 10-13) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.
Original language | English |
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Pages (from-to) | 848-850 |
Number of pages | 3 |
Journal | Nature Neuroscience |
Volume | 16 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2013 |
ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)