CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure

Marco Valgimigli, Gian Matteo Rigolin, Alessandro Fucili, Matteo Della Porta, Olga Soukhomovskaia, Patrizia Malagutti, Anna Maria Bugli, Letizia Zenone Bragotti, Gloria Francolini, Endri Mauro, Gianluigi Castoldi, Roberto Ferrari

Research output: Contribution to journalArticle

318 Citations (Scopus)

Abstract

Background-Peripheral blood CD34+ cells and circulating endothelial progenitor cells (EPCs) increase in myocardial infarction and vascular injuries as a reflection of endothelial damage. Despite the occurrence of endothelial dysfunction in heart failure (HF), no data are available on EPC mobilization in this setting. We investigated the pattern of CD34+ cells and EPC mobilization during HF and their correlation with the severity and origin of the disease. Methods and Results-Peripheral blood CD34+ cells (n=91) and EPCs (n=41), assessed both as CD34+ cells coexpressing AC133 and vascular endothelial growth factor (VEGF) receptor-2 and as endothelial colony-forming units, were studied in HF patients (mean age 67±11 years) and 45 gender- and age-matched controls. Tumor necrosis factor-α (TNF-α) and its receptors (sTNFR-1 and sTNFR-2), VEGF, stromal derived factor-1 (SDF-1), granulocyte-colony stimulating factor (G-CSF), and B-type natriuretic peptide were also measured. CD34+ cells, EPCs, TNF-α and receptors, VEGF, SDF-1, and B-type natriuretic peptide were increased in HF. CD34+ cells and EPCs were inversely related to functional class and to TNF-α, being decreased in New York Heart Association class IV compared with class I and II and controls. No role was found for the origin of the disease. Conclusions-CD34+ cells and EPC mobilization occurs in HF and shows a biphasic response, with elevation and depression in the early and advanced phases, respectively. This could be related to the myelosuppressive role of TNF-α.

Original languageEnglish
Pages (from-to)1209-1212
Number of pages4
JournalCirculation
Volume110
Issue number10
DOIs
Publication statusPublished - Sep 7 2004

Fingerprint

Heart Failure
Tumor Necrosis Factor Receptors
Brain Natriuretic Peptide
Vascular Endothelial Growth Factor A
Blood Cells
Tumor Necrosis Factor-alpha
Vascular Endothelial Growth Factor Receptor-2
Vascular System Injuries
Granulocyte Colony-Stimulating Factor
Endothelial Progenitor Cells
Stem Cells
Myocardial Infarction

Keywords

  • Angiogenesis
  • Cells
  • Endothelium
  • Heart failure
  • Interleukins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Valgimigli, M., Rigolin, G. M., Fucili, A., Della Porta, M., Soukhomovskaia, O., Malagutti, P., ... Ferrari, R. (2004). CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation, 110(10), 1209-1212. https://doi.org/10.1161/01.CIR.0000136813.89036.21

CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. / Valgimigli, Marco; Rigolin, Gian Matteo; Fucili, Alessandro; Della Porta, Matteo; Soukhomovskaia, Olga; Malagutti, Patrizia; Bugli, Anna Maria; Bragotti, Letizia Zenone; Francolini, Gloria; Mauro, Endri; Castoldi, Gianluigi; Ferrari, Roberto.

In: Circulation, Vol. 110, No. 10, 07.09.2004, p. 1209-1212.

Research output: Contribution to journalArticle

Valgimigli, M, Rigolin, GM, Fucili, A, Della Porta, M, Soukhomovskaia, O, Malagutti, P, Bugli, AM, Bragotti, LZ, Francolini, G, Mauro, E, Castoldi, G & Ferrari, R 2004, 'CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure', Circulation, vol. 110, no. 10, pp. 1209-1212. https://doi.org/10.1161/01.CIR.0000136813.89036.21
Valgimigli, Marco ; Rigolin, Gian Matteo ; Fucili, Alessandro ; Della Porta, Matteo ; Soukhomovskaia, Olga ; Malagutti, Patrizia ; Bugli, Anna Maria ; Bragotti, Letizia Zenone ; Francolini, Gloria ; Mauro, Endri ; Castoldi, Gianluigi ; Ferrari, Roberto. / CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. In: Circulation. 2004 ; Vol. 110, No. 10. pp. 1209-1212.
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T1 - CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure

AU - Valgimigli, Marco

AU - Rigolin, Gian Matteo

AU - Fucili, Alessandro

AU - Della Porta, Matteo

AU - Soukhomovskaia, Olga

AU - Malagutti, Patrizia

AU - Bugli, Anna Maria

AU - Bragotti, Letizia Zenone

AU - Francolini, Gloria

AU - Mauro, Endri

AU - Castoldi, Gianluigi

AU - Ferrari, Roberto

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N2 - Background-Peripheral blood CD34+ cells and circulating endothelial progenitor cells (EPCs) increase in myocardial infarction and vascular injuries as a reflection of endothelial damage. Despite the occurrence of endothelial dysfunction in heart failure (HF), no data are available on EPC mobilization in this setting. We investigated the pattern of CD34+ cells and EPC mobilization during HF and their correlation with the severity and origin of the disease. Methods and Results-Peripheral blood CD34+ cells (n=91) and EPCs (n=41), assessed both as CD34+ cells coexpressing AC133 and vascular endothelial growth factor (VEGF) receptor-2 and as endothelial colony-forming units, were studied in HF patients (mean age 67±11 years) and 45 gender- and age-matched controls. Tumor necrosis factor-α (TNF-α) and its receptors (sTNFR-1 and sTNFR-2), VEGF, stromal derived factor-1 (SDF-1), granulocyte-colony stimulating factor (G-CSF), and B-type natriuretic peptide were also measured. CD34+ cells, EPCs, TNF-α and receptors, VEGF, SDF-1, and B-type natriuretic peptide were increased in HF. CD34+ cells and EPCs were inversely related to functional class and to TNF-α, being decreased in New York Heart Association class IV compared with class I and II and controls. No role was found for the origin of the disease. Conclusions-CD34+ cells and EPC mobilization occurs in HF and shows a biphasic response, with elevation and depression in the early and advanced phases, respectively. This could be related to the myelosuppressive role of TNF-α.

AB - Background-Peripheral blood CD34+ cells and circulating endothelial progenitor cells (EPCs) increase in myocardial infarction and vascular injuries as a reflection of endothelial damage. Despite the occurrence of endothelial dysfunction in heart failure (HF), no data are available on EPC mobilization in this setting. We investigated the pattern of CD34+ cells and EPC mobilization during HF and their correlation with the severity and origin of the disease. Methods and Results-Peripheral blood CD34+ cells (n=91) and EPCs (n=41), assessed both as CD34+ cells coexpressing AC133 and vascular endothelial growth factor (VEGF) receptor-2 and as endothelial colony-forming units, were studied in HF patients (mean age 67±11 years) and 45 gender- and age-matched controls. Tumor necrosis factor-α (TNF-α) and its receptors (sTNFR-1 and sTNFR-2), VEGF, stromal derived factor-1 (SDF-1), granulocyte-colony stimulating factor (G-CSF), and B-type natriuretic peptide were also measured. CD34+ cells, EPCs, TNF-α and receptors, VEGF, SDF-1, and B-type natriuretic peptide were increased in HF. CD34+ cells and EPCs were inversely related to functional class and to TNF-α, being decreased in New York Heart Association class IV compared with class I and II and controls. No role was found for the origin of the disease. Conclusions-CD34+ cells and EPC mobilization occurs in HF and shows a biphasic response, with elevation and depression in the early and advanced phases, respectively. This could be related to the myelosuppressive role of TNF-α.

KW - Angiogenesis

KW - Cells

KW - Endothelium

KW - Heart failure

KW - Interleukins

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