CD34+-Selected stem cell boost without further conditioning for poor graft function after allogeneic stem cell transplantation in patients with hematological malignancies

Evgeny Klyuchnikov, Jean El-Cheikh, Andreas Sputtek, Michael Lioznov, Boris Calmels, Sabine Furst, Christian Chabannon, Roberto Crocchiolo, Claude Lemarié, Catherine Faucher, Ulrike Bacher, Haefaa Alchalby, Thomas Stübig, Christine Wolschke, Francis Ayuk, Marie Luise Reckhaus, Didier Blaise, Nicolaus Kröger

Research output: Contribution to journalArticle

Abstract

We retrospectively analyzed outcomes of a CD34+-selected stem cell boost (SCB) without prior conditioning in 32 patients (male/22; median age of 54 years; range, 20 to 69) with poor graft function, defined as neutrophils ≤1.5 x 109/L, and/or platelets ≤30 x 109/L, and/or hemoglobin ≤8.5 g/dL). The median interval between stem cell transplantation and SCB was 5 months (range, 2 to 228). The median number of CD34+ and CD3+ cells were 3.4 x 106/kg (.96 to 8.30) and 9 x 103/kg body weight (range, 2 to 70), respectively. Hematological improvement was observed in 81% of patients and noted after a median of 30 days (range, 14 to 120) after SCB. The recipients of related grafts responded faster than recipients of unrelated grafts (20 versus 30 days, P= .04). The cumulative incidence of acute (grade II to IV) and chronic graft-versus-host disease (GVHD) after SCB was 17% and 26%, respectively. Patients with acute GVHD received a higher median CD3+ cell dose. The 2-year probability of overall survival was 45%. We suggest that SCB represents an effective approach to improve poor graft function post transplantation, but optimal timing of SCB administration, anti-infective, and GVHD prophylaxis needs further evaluation.

Original languageEnglish
Pages (from-to)382-386
Number of pages5
JournalBiology of Blood and Marrow Transplantation
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Allogeneic hematopoietic stem cell transplantation (HSCT)
  • CD34-selected cells
  • Poor graft function
  • Stem cell boost

ASJC Scopus subject areas

  • Transplantation
  • Hematology

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    Klyuchnikov, E., El-Cheikh, J., Sputtek, A., Lioznov, M., Calmels, B., Furst, S., Chabannon, C., Crocchiolo, R., Lemarié, C., Faucher, C., Bacher, U., Alchalby, H., Stübig, T., Wolschke, C., Ayuk, F., Reckhaus, M. L., Blaise, D., & Kröger, N. (2014). CD34+-Selected stem cell boost without further conditioning for poor graft function after allogeneic stem cell transplantation in patients with hematological malignancies. Biology of Blood and Marrow Transplantation, 20(3), 382-386. https://doi.org/10.1016/j.bbmt.2013.11.034