CD34+-selected versus unmanipulated autologous stem cell transplantation in multiple myeloma: Impact on dendritic and immune recovery and on complications due to infection

D. Damiani, R. Stocchi, P. Masolini, A. Michelutti, A. Geromin, A. Sperotto, C. Skert, M. Michieli, M. Baccarani, R. Fanin

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Large-scale CD34+ enrichment has been demonstrated a safe method in autologous transplantation for multiple myeloma. However, the high CD34+ enrichment and the consequent plasma cell purging result in concomitant T-cell and dendritic-cell (DC) depletion, theoretically increasing the risk of life-threatening infections. Patients and methods: We evaluated immunological and dendritic reconstitution in 72 myeloma patients who had undergone CD34+-selected (n = 45) and unmanipulated (n = 27) stem cell transplant, and its correlation with infections. Results: Haematological recovery occurred promptly in all patients. Only a slight delay in platelet recovery to >50 × 109/l was observed in patients receiving CD34+-enriched graft. Natural killer (NK) cell count recovered in all patients within 2 months and B-cell count had recovered by 6 months post-transplant in both groups. CD3 cells remained lower than normal in both groups. CD8 cells increased above the normal level, reaching a peak at day 90, and lowered to normal level within 1 year post-transplant. CD4 lymphocytes remained

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalAnnals of Oncology
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

Keywords

  • CD34 selection
  • Infections
  • Multiple myeloma
  • Transplantation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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