CD4 and CD4/CD8 ratio progression in HIV-HCV infected patients after achievement of SVR

A. Saracino, G. Bruno, L. Scudeller, N. Ladisa, N. de Gennaro, M. Allegrini, L. Monno, G. Angarano

Research output: Contribution to journalArticle

Abstract

Background In HIV-HCV co-infected patients, the long-term effects of HCV eradication on HIV disease progression are still unclear. Objectives This study aims to determine if CD4 and CD4/CD8 ratio slopes improved after anti-HCV treatment in patients achieving a sustained virological response (SVR). Study design A total of 116 HIV-HCV co-infected patients, previously treated with Peg-IFN/RBV, were divided into two groups: SVR (55 patients who had achieved SVR), and non-SVR (61 patients). Retrospective data before and after anti-HCV therapy were obtained for all patients, with a median 8 year-follow-up. Multilevel mixed models were fitted to assess the trends over time of FIB-4 score, APRI score, CD4, CD8 cell count and CD4/CD8 ratio. Results Median HIV-infection duration, HCV-RNA and GGT baseline levels were higher in non-SVR compared to the SVR group. A significantly decreased FIB-4 (p 

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalJournal of Clinical Virology
Volume81
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • APRI
  • CD4
  • CD4/CD8 ratio
  • FIB-4
  • HIV-HCV co-infection
  • Liver fibrosis
  • SVR

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Saracino, A., Bruno, G., Scudeller, L., Ladisa, N., de Gennaro, N., Allegrini, M., Monno, L., & Angarano, G. (2016). CD4 and CD4/CD8 ratio progression in HIV-HCV infected patients after achievement of SVR. Journal of Clinical Virology, 81, 94-99. https://doi.org/10.1016/j.jcv.2016.05.019