CD46 is a cellular receptor for human herpesvirus 6

Fabio Santoro, Paul E. Kennedy, Giuseppe Locatelli, Mauro S. Malnati, Edward A. Berger, Paolo Lusso

Research output: Contribution to journalArticle

Abstract

Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthema subitum, causes opportunistic infections in immunocompromised patients, and has been implicated in multiple sclerosis and in the progression of AIDS. Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor. Downregulation of surface CD46 was documented during the course of HHV-6 infection. Both acute infection and cell fusion mediated by HHV-6 were specifically inhibited by a monoclonal antibody to CD46; fusion was also blocked by soluble CD46. Nonhuman cells that were resistant to HHV-6 fusion and entry became susceptible upon expression of recombinant human CD46. The use of a ubiquitous immunoregulatory receptor opens novel perspectives for understanding the tropism and pathogenicity of HHV-6.

Original languageEnglish
Pages (from-to)817-827
Number of pages11
JournalCell
Volume99
Issue number7
Publication statusPublished - Dec 23 1999

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Human Herpesvirus 6
Fusion reactions
Exanthema Subitum
Monoclonal Antibodies
Herpesviridae Infections
Tropism
Cell Fusion
Opportunistic Infections
Immunocompromised Host
Multiple Sclerosis
Virulence
Acquired Immunodeficiency Syndrome
Down-Regulation
Infection

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Santoro, F., Kennedy, P. E., Locatelli, G., Malnati, M. S., Berger, E. A., & Lusso, P. (1999). CD46 is a cellular receptor for human herpesvirus 6. Cell, 99(7), 817-827.

CD46 is a cellular receptor for human herpesvirus 6. / Santoro, Fabio; Kennedy, Paul E.; Locatelli, Giuseppe; Malnati, Mauro S.; Berger, Edward A.; Lusso, Paolo.

In: Cell, Vol. 99, No. 7, 23.12.1999, p. 817-827.

Research output: Contribution to journalArticle

Santoro, F, Kennedy, PE, Locatelli, G, Malnati, MS, Berger, EA & Lusso, P 1999, 'CD46 is a cellular receptor for human herpesvirus 6', Cell, vol. 99, no. 7, pp. 817-827.
Santoro F, Kennedy PE, Locatelli G, Malnati MS, Berger EA, Lusso P. CD46 is a cellular receptor for human herpesvirus 6. Cell. 1999 Dec 23;99(7):817-827.
Santoro, Fabio ; Kennedy, Paul E. ; Locatelli, Giuseppe ; Malnati, Mauro S. ; Berger, Edward A. ; Lusso, Paolo. / CD46 is a cellular receptor for human herpesvirus 6. In: Cell. 1999 ; Vol. 99, No. 7. pp. 817-827.
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