CD4+CD28null T lymphocyte frequency, a new marker of cardiovascular risk: Relationship with polycystic ovary syndrome phenotypes

Francesca Moro, Andrea Morciano, Anna Tropea, Francesca Sagnella, Carola Palla, Elisa Scarinci, Nicola Cosentino, Giampaolo Niccoli, Giovanna Liuzzo, Filippo Crea, Antonio Lanzone, Rosanna Apa

Research output: Contribution to journalArticlepeer-review


Objective: To study the frequency of CD4+CD28null T cells, which are aggressive T lymphocytes associated with recurrent coronary instability and type 2 diabetes mellitus, in different polycystic ovary syndrome (PCOS) phenotypes and in age- and body mass index-matched healthy women. Design: Retrospective cohort observational study. Setting: Unit of human reproductive pathophysiology, university hospital. Patient(s): A total of 167 PCOS patients and 102 control subjects. Intervention(s): None. Main Outcome Measure(s): CD4+CD28null T cell frequency, high-sensitive C-reactive protein levels, and other glucose-metabolic parameters. Result(s): CD4+CD28null frequency was significantly higher in all PCOS groups than in control subjects. CD4+CD28null frequency was significantly higher in nonhyperandrogenic phenotype (5.7%, range 3.2-7.1) than in phenotypes with hyperandrogenism (H) + oligoamenorrhea (O) + polycystic ovary (PCO) (3.5%, range 1-5.8), H + O (3%, range 1.8-4.7), and H + PCO (2.63%, range 1.2-4.1). The relative risk of non-H phenotype for PCOS women in the highest quartile for CD4+CD28null frequency compared with PCOS women with the lowest quartile was 3.2 (95% confidence interval 1.9-5.8). Conclusion(s): Cardiovascular risk evaluation should be performed in all PCOS phenotypes. In particular, we demonstrated that the non-H phenotype has potentially increased cardiovascular risk in terms of CD4 +CD28null frequency.

Original languageEnglish
Pages (from-to)1609-1615
Number of pages7
JournalFertility and Sterility
Issue number6
Publication statusPublished - Dec 2012


  • cardiovascular risk
  • CD4CD28
  • phenotypes
  • Polycystic ovary syndrome
  • Rotterdam criteria

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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