TY - JOUR
T1 - CD4+CD28null T lymphocyte frequency, a new marker of cardiovascular risk
T2 - Relationship with polycystic ovary syndrome phenotypes
AU - Moro, Francesca
AU - Morciano, Andrea
AU - Tropea, Anna
AU - Sagnella, Francesca
AU - Palla, Carola
AU - Scarinci, Elisa
AU - Cosentino, Nicola
AU - Niccoli, Giampaolo
AU - Liuzzo, Giovanna
AU - Crea, Filippo
AU - Lanzone, Antonio
AU - Apa, Rosanna
PY - 2012/12
Y1 - 2012/12
N2 - Objective: To study the frequency of CD4+CD28null T cells, which are aggressive T lymphocytes associated with recurrent coronary instability and type 2 diabetes mellitus, in different polycystic ovary syndrome (PCOS) phenotypes and in age- and body mass index-matched healthy women. Design: Retrospective cohort observational study. Setting: Unit of human reproductive pathophysiology, university hospital. Patient(s): A total of 167 PCOS patients and 102 control subjects. Intervention(s): None. Main Outcome Measure(s): CD4+CD28null T cell frequency, high-sensitive C-reactive protein levels, and other glucose-metabolic parameters. Result(s): CD4+CD28null frequency was significantly higher in all PCOS groups than in control subjects. CD4+CD28null frequency was significantly higher in nonhyperandrogenic phenotype (5.7%, range 3.2-7.1) than in phenotypes with hyperandrogenism (H) + oligoamenorrhea (O) + polycystic ovary (PCO) (3.5%, range 1-5.8), H + O (3%, range 1.8-4.7), and H + PCO (2.63%, range 1.2-4.1). The relative risk of non-H phenotype for PCOS women in the highest quartile for CD4+CD28null frequency compared with PCOS women with the lowest quartile was 3.2 (95% confidence interval 1.9-5.8). Conclusion(s): Cardiovascular risk evaluation should be performed in all PCOS phenotypes. In particular, we demonstrated that the non-H phenotype has potentially increased cardiovascular risk in terms of CD4 +CD28null frequency.
AB - Objective: To study the frequency of CD4+CD28null T cells, which are aggressive T lymphocytes associated with recurrent coronary instability and type 2 diabetes mellitus, in different polycystic ovary syndrome (PCOS) phenotypes and in age- and body mass index-matched healthy women. Design: Retrospective cohort observational study. Setting: Unit of human reproductive pathophysiology, university hospital. Patient(s): A total of 167 PCOS patients and 102 control subjects. Intervention(s): None. Main Outcome Measure(s): CD4+CD28null T cell frequency, high-sensitive C-reactive protein levels, and other glucose-metabolic parameters. Result(s): CD4+CD28null frequency was significantly higher in all PCOS groups than in control subjects. CD4+CD28null frequency was significantly higher in nonhyperandrogenic phenotype (5.7%, range 3.2-7.1) than in phenotypes with hyperandrogenism (H) + oligoamenorrhea (O) + polycystic ovary (PCO) (3.5%, range 1-5.8), H + O (3%, range 1.8-4.7), and H + PCO (2.63%, range 1.2-4.1). The relative risk of non-H phenotype for PCOS women in the highest quartile for CD4+CD28null frequency compared with PCOS women with the lowest quartile was 3.2 (95% confidence interval 1.9-5.8). Conclusion(s): Cardiovascular risk evaluation should be performed in all PCOS phenotypes. In particular, we demonstrated that the non-H phenotype has potentially increased cardiovascular risk in terms of CD4 +CD28null frequency.
KW - cardiovascular risk
KW - CD4CD28
KW - phenotypes
KW - Polycystic ovary syndrome
KW - Rotterdam criteria
UR - http://www.scopus.com/inward/record.url?scp=84870340449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870340449&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2012.08.015
DO - 10.1016/j.fertnstert.2012.08.015
M3 - Article
C2 - 22963806
AN - SCOPUS:84870340449
VL - 98
SP - 1609
EP - 1615
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 6
ER -