CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Giampaolo Niccoli; Rosanna Apa; Antonio Lanzone; Giovanna Liuzzo; Cristina Spaziani; Francesca Sagnella; Nicola Cosentino; Francesca Moro; Daniela Martinez; Andrea Morciano; Marco Bac; Vincenzo Pazzano; Maria Francesca Gangale; Anna Tropea; Filippo Crea

doi:10.1016/j.fertnstert.2011.01.129

CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Giampaolo Niccoli, Rosanna Apa, Antonio Lanzone, Giovanna Liuzzo, Cristina Spaziani, Francesca Sagnella, Nicola Cosentino, Francesca Moro, Daniela Martinez, Andrea Morciano, Marco Bac, Vincenzo Pazzano, Maria Francesca Gangale, Anna Tropea, Filippo Crea

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4⁺CD28^null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

Original language	English
Pages (from-to)	2651-2654
Number of pages	4
Journal	Fertility and Sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.01.129
Publication status	Published - Jun 30 2011

Keywords

Hyperinsulinemia
inflammation
polycystic ovary syndrome
T lymphocytes

ASJC Scopus subject areas

Obstetrics and Gynaecology
Reproductive Medicine

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10.1016/j.fertnstert.2011.01.129

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Niccoli, G., Apa, R., Lanzone, A., Liuzzo, G., Spaziani, C., Sagnella, F., Cosentino, N., Moro, F., Martinez, D., Morciano, A., Bac, M., Pazzano, V., Gangale, M. F., Tropea, A., & Crea, F. (2011). CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome. Fertility and Sterility, 95(8), 2651-2654. https://doi.org/10.1016/j.fertnstert.2011.01.129

CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome. / Niccoli, Giampaolo; Apa, Rosanna; Lanzone, Antonio; Liuzzo, Giovanna; Spaziani, Cristina; Sagnella, Francesca; Cosentino, Nicola; Moro, Francesca; Martinez, Daniela; Morciano, Andrea; Bac, Marco; Pazzano, Vincenzo; Gangale, Maria Francesca; Tropea, Anna; Crea, Filippo.

In: Fertility and Sterility, Vol. 95, No. 8, 30.06.2011, p. 2651-2654.

Research output: Contribution to journal › Article › peer-review

Niccoli, G, Apa, R, Lanzone, A, Liuzzo, G, Spaziani, C, Sagnella, F, Cosentino, N, Moro, F, Martinez, D, Morciano, A, Bac, M, Pazzano, V, Gangale, MF, Tropea, A & Crea, F 2011, 'CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome', Fertility and Sterility, vol. 95, no. 8, pp. 2651-2654. https://doi.org/10.1016/j.fertnstert.2011.01.129

Niccoli, Giampaolo ; Apa, Rosanna ; Lanzone, Antonio ; Liuzzo, Giovanna ; Spaziani, Cristina ; Sagnella, Francesca ; Cosentino, Nicola ; Moro, Francesca ; Martinez, Daniela ; Morciano, Andrea ; Bac, Marco ; Pazzano, Vincenzo ; Gangale, Maria Francesca ; Tropea, Anna ; Crea, Filippo. / CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome. In: Fertility and Sterility. 2011 ; Vol. 95, No. 8. pp. 2651-2654.

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abstract = "Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.",

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AU - Moro, Francesca

AU - Martinez, Daniela

AU - Morciano, Andrea

AU - Bac, Marco

AU - Pazzano, Vincenzo

AU - Gangale, Maria Francesca

AU - Tropea, Anna

AU - Crea, Filippo

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