CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Giampaolo Niccoli, Rosanna Apa, Antonio Lanzone, Giovanna Liuzzo, Cristina Spaziani, Francesca Sagnella, Nicola Cosentino, Francesca Moro, Daniela Martinez, Andrea Morciano, Marco Bac, Vincenzo Pazzano, Maria Francesca Gangale, Anna Tropea, Filippo Crea

Research output: Contribution to journalArticlepeer-review


Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

Original languageEnglish
Pages (from-to)2651-2654
Number of pages4
JournalFertility and Sterility
Issue number8
Publication statusPublished - Jun 30 2011


  • Hyperinsulinemia
  • inflammation
  • polycystic ovary syndrome
  • T lymphocytes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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