CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Giampaolo Niccoli; Rosanna Apa; Antonio Lanzone; Giovanna Liuzzo; Cristina Spaziani; Francesca Sagnella; Nicola Cosentino; Francesca Moro; Daniela Martinez; Andrea Morciano; Marco Bac; Vincenzo Pazzano; Maria Francesca Gangale; Anna Tropea; Filippo Crea

doi:10.1016/j.fertnstert.2011.01.129

CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Giampaolo Niccoli, Rosanna Apa, Antonio Lanzone, Giovanna Liuzzo, Cristina Spaziani, Francesca Sagnella, Nicola Cosentino, Francesca Moro, Daniela Martinez, Andrea Morciano, Marco Bac, Vincenzo Pazzano, Maria Francesca Gangale, Anna Tropea, Filippo Crea

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4⁺CD28^null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

Original language	English
Pages (from-to)	2651-2654
Number of pages	4
Journal	Fertility and Sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.01.129
Publication status	Published - Jun 30 2011

Keywords

Hyperinsulinemia
inflammation
polycystic ovary syndrome
T lymphocytes

ASJC Scopus subject areas

Obstetrics and Gynaecology
Reproductive Medicine

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10.1016/j.fertnstert.2011.01.129

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Niccoli, G., Apa, R., Lanzone, A., Liuzzo, G., Spaziani, C., Sagnella, F., Cosentino, N., Moro, F., Martinez, D., Morciano, A., Bac, M., Pazzano, V., Gangale, M. F., Tropea, A., & Crea, F. (2011). CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome. Fertility and Sterility, 95(8), 2651-2654. https://doi.org/10.1016/j.fertnstert.2011.01.129

Niccoli, G, Apa, R, Lanzone, A, Liuzzo, G, Spaziani, C, Sagnella, F, Cosentino, N, Moro, F, Martinez, D, Morciano, A, Bac, M, Pazzano, V, Gangale, MF, Tropea, A & Crea, F 2011, 'CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome', Fertility and Sterility, vol. 95, no. 8, pp. 2651-2654. https://doi.org/10.1016/j.fertnstert.2011.01.129

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title = "CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome",

abstract = "Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.",

keywords = "Hyperinsulinemia, inflammation, polycystic ovary syndrome, T lymphocytes",

author = "Giampaolo Niccoli and Rosanna Apa and Antonio Lanzone and Giovanna Liuzzo and Cristina Spaziani and Francesca Sagnella and Nicola Cosentino and Francesca Moro and Daniela Martinez and Andrea Morciano and Marco Bac and Vincenzo Pazzano and Gangale, {Maria Francesca} and Anna Tropea and Filippo Crea",

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doi = "10.1016/j.fertnstert.2011.01.129",

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T1 - CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

AU - Niccoli, Giampaolo

AU - Apa, Rosanna

AU - Lanzone, Antonio

AU - Liuzzo, Giovanna

AU - Spaziani, Cristina

AU - Sagnella, Francesca

AU - Cosentino, Nicola

AU - Moro, Francesca

AU - Martinez, Daniela

AU - Morciano, Andrea

AU - Bac, Marco

AU - Pazzano, Vincenzo

AU - Gangale, Maria Francesca

AU - Tropea, Anna

AU - Crea, Filippo

PY - 2011/6/30

Y1 - 2011/6/30

N2 - Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

AB - Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

KW - Hyperinsulinemia

KW - inflammation

KW - polycystic ovary syndrome

KW - T lymphocytes

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CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Abstract

Keywords

ASJC Scopus subject areas

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