CD5 - diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case

Marco Lucioni, Francesca Novara, Roberta Riboni, Giacomo Fiandrino, Marta Nicola, Sandra Kindl, Emanuela Boveri, Vassili Jemos, Luca Arcaini, Orsetta Zuffardi, Marco Paulli

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Increased expression of cyclin D1 is notoriously associated with mantle cell lymphoma because of translocation t(11;14)(q13;q32) or variants involving the cyclin D1 gene. We present an unusual case of CD5-negative diffuse large B-cell lymphoma expressing cyclin D1 in the absence of translocation by fluorescence in situ hybridization analysis. Using array-comparative genomic hybridization, we found a complex karyotype without the characteristic chromosomal aberrations accompanying cyclin D1 translocation in mantle cell lymphoma; instead, there was monoallelic deletion of AKT interacting protein and glycogen synthase kinase-3 β genes, both involved in the AKT/glycogen synthase kinase-3 β cascade-controlling nuclear levels of cyclin D1. These findings suggest that posttranslational events regulating cyclin D1 activity may take place also in a subset of diffuse large B-cell lymphomas and contribute to lymphomagenesis. As a consequence, the sole cyclin D1 positivity by immunohistochemistry may not be enough to distinguish pleomorphic/blastoid mantle cell lymphoma from diffuse large B-cell lymphoma. Search for t(11;14) with fluorescence in situ hybridization probes should always be performed in doubtful cases.

Original languageEnglish
Pages (from-to)1204-1208
Number of pages5
JournalHuman Pathology
Volume42
Issue number8
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Cyclin D1
Phenotype
Mantle-Cell Lymphoma
Glycogen Synthase Kinase 3
Fluorescence In Situ Hybridization
bcl-1 Genes
Comparative Genomic Hybridization
Karyotype
Chromosome Aberrations
Immunohistochemistry
Genes
Proteins

Keywords

  • Array comparative genomic hybridization
  • Cyclin D1
  • Diffuse large B-cell lymphoma
  • Mantle cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

CD5 - diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case. / Lucioni, Marco; Novara, Francesca; Riboni, Roberta; Fiandrino, Giacomo; Nicola, Marta; Kindl, Sandra; Boveri, Emanuela; Jemos, Vassili; Arcaini, Luca; Zuffardi, Orsetta; Paulli, Marco.

In: Human Pathology, Vol. 42, No. 8, 08.2011, p. 1204-1208.

Research output: Contribution to journalArticle

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AU - Nicola, Marta

AU - Kindl, Sandra

AU - Boveri, Emanuela

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