CD56/neural cell adhesion molecule expression in primary extranodal Ki- 1/CD30+ lymphoma: Report of a pediatric case with simultaneous cutaneous and bone localizations

Marco Paulli, Emanuela Boveri, Renato Rosso, Maurizio Aricò, Sandra Kindl, Alessandra Viglio, Emilio Berti, Frank Leithäuser, Franco Locatelli, Umberto Gianelli, Giampiero Beluffi, Alfred C. Feller, Giovanni Borroni, Umberto Magrini

Research output: Contribution to journalArticle

Abstract

We describe the clinicopathologic features of an unusual case of CD30+/CD56+ T-cell lymphoma in a child who presented with simultaneous primary extranodal cutaneous and bone localizations. The expression of CD56 (neural cell adhesion molecule, or NCAM) is rare in non-Hodgkin's lymphomas other than in a group of haematopoietic/lymphoid neoplasms of natural killer and natural killer-like T cells, which usually involve extranodal sites and often pursue an aggressive clinical behavior. Coexpression of CD30 and CD56 in T-cell lymphomas is exceedingly rare, and its biological significance is unknown. Our patient responded well to an intensive chemotherapy regimen, and she is now in complete remission 4 years after discontinuation of chemotherapy. Expression of NCAM could he regarded as responsible, in part, for the extranodal localization of lymphoma cells; expression of CD56 also might contribute to the definition of a subset of CD30+ lymphomas with distinctive clinicopathologic features.

Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalAmerican Journal of Dermatopathology
Volume19
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • CD56/NCAM antigen
  • Extranodal CD30+ lymphomas
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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