TY - JOUR
T1 - CD56/neural cell adhesion molecule expression in primary extranodal Ki- 1/CD30+ lymphoma
T2 - Report of a pediatric case with simultaneous cutaneous and bone localizations
AU - Paulli, Marco
AU - Boveri, Emanuela
AU - Rosso, Renato
AU - Aricò, Maurizio
AU - Kindl, Sandra
AU - Viglio, Alessandra
AU - Berti, Emilio
AU - Leithäuser, Frank
AU - Locatelli, Franco
AU - Gianelli, Umberto
AU - Beluffi, Giampiero
AU - Feller, Alfred C.
AU - Borroni, Giovanni
AU - Magrini, Umberto
PY - 1997
Y1 - 1997
N2 - We describe the clinicopathologic features of an unusual case of CD30+/CD56+ T-cell lymphoma in a child who presented with simultaneous primary extranodal cutaneous and bone localizations. The expression of CD56 (neural cell adhesion molecule, or NCAM) is rare in non-Hodgkin's lymphomas other than in a group of haematopoietic/lymphoid neoplasms of natural killer and natural killer-like T cells, which usually involve extranodal sites and often pursue an aggressive clinical behavior. Coexpression of CD30 and CD56 in T-cell lymphomas is exceedingly rare, and its biological significance is unknown. Our patient responded well to an intensive chemotherapy regimen, and she is now in complete remission 4 years after discontinuation of chemotherapy. Expression of NCAM could he regarded as responsible, in part, for the extranodal localization of lymphoma cells; expression of CD56 also might contribute to the definition of a subset of CD30+ lymphomas with distinctive clinicopathologic features.
AB - We describe the clinicopathologic features of an unusual case of CD30+/CD56+ T-cell lymphoma in a child who presented with simultaneous primary extranodal cutaneous and bone localizations. The expression of CD56 (neural cell adhesion molecule, or NCAM) is rare in non-Hodgkin's lymphomas other than in a group of haematopoietic/lymphoid neoplasms of natural killer and natural killer-like T cells, which usually involve extranodal sites and often pursue an aggressive clinical behavior. Coexpression of CD30 and CD56 in T-cell lymphomas is exceedingly rare, and its biological significance is unknown. Our patient responded well to an intensive chemotherapy regimen, and she is now in complete remission 4 years after discontinuation of chemotherapy. Expression of NCAM could he regarded as responsible, in part, for the extranodal localization of lymphoma cells; expression of CD56 also might contribute to the definition of a subset of CD30+ lymphomas with distinctive clinicopathologic features.
KW - CD56/NCAM antigen
KW - Extranodal CD30+ lymphomas
KW - Immunohistochemistry
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U2 - 10.1097/00000372-199708000-00011
DO - 10.1097/00000372-199708000-00011
M3 - Article
C2 - 9261474
AN - SCOPUS:0030663580
VL - 19
SP - 384
EP - 390
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 4
ER -