CD62, thromboxane B2, and beta-thromboglobulin: A comparison between different markers of platelet activation after contact with biomaterials

E. Cenni, D. Granchi, E. Verri, D. Cavedagna, S. Gamberini, G. Falsone, A. Pizzoferrato

Research output: Contribution to journalArticlepeer-review

Abstract

The authors examined the modifications of some markers of platelet activation after contact with biomaterials. Glycoprotein GMP-140 (CD62) was evaluated by flow cytometry; β-thromboglobulin (β-TG) and thromboxane B2 (TXB2) were determined by radioimmunoassay. Polyethylene terephthalate (PET) induced a remarkable platelet adhesion and a significant increase in β-TG and TXB2, with no increase in CD62 on the nonadherent platelets. Pyrolytic carbon-coated PET (PC) did not induce platelet adhesion after 15 min of contact, but a significant increase in CD62 was detected. After 30 min a significant increase in platelet adhesion as well as the release of β-TG and TXB2 were noted. The increase was lower than that observed for uncoated PET, and after 30 min of contact with PC the increase no longer was observed.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalJournal of Biomedical Materials Research
Volume36
Issue number3
DOIs
Publication statusPublished - Sep 5 1997

Keywords

  • Biomaterial
  • GMP-140
  • Platelet
  • Release reaction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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