CD69 expression on primitive progenitor cells and hematopoietic malignancies

P. Tassone, M. C. Turco, F. Tuccillo, P. Bonelli, G. Morrone, L. Cecco, M. Cerra, H. Bond, M. Di Nicola, A. M. Gianni, S. Venuta

Research output: Contribution to journalArticlepeer-review

Abstract

CD69 is an early activation antigen of peripheral blood lymphocytes and is constitutively expressed on a wide variety of bone marrow-derived cells. To further characterize the distribution and understand the potential biological role of the molecule in normal and malignant hematopoiesis, we used a novel high affinity anti-CD69 mAb (UN6) and analyzed hematopoietic progenitor cells together with a panel of myeloid and lymphoid malignancies. We report that mobilized peripheral blood CD34+ cells display detectable levels of CD69 and that the density of membrane expression correlates with the immature phenotype CD34(bright) Thy-1(bright) cells. Furthermore, during cytokine-induced differentiation, the expression of CD69 is moderately down-regulated. Analysis of hematopoietic malignancies revealed that CD69 expression correlates with the immature myeloid phenotype. Taken together these data suggest a role of CD69 during the early phase of hematopoiesis and in the leukemic transformation.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalTissue Antigens
Volume48
Issue number1
Publication statusPublished - 1996

Keywords

  • CD34 progenitor cell
  • CD69
  • Myeloid leukemia
  • UN6

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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