CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells

Alessia Grozio; Giovanna Sociali; Laura Sturla; Irene Caffa; Debora Soncini; Annalisa Salis; Nadia Raffaelli; Antonio De Flora; Alessio Nencioni; Santina Bruzzone

doi:10.1074/jbc.M113.470435

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells

Alessia Grozio, Giovanna Sociali, Laura Sturla, Irene Caffa, Debora Soncini, Annalisa Salis, Nadia Raffaelli, Antonio De Flora, Alessio Nencioni, Santina Bruzzone

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: NAMPT inhibitors showed antitumor activity in preclinical cancer models, but no tumor remission occurred in clinical studies. Results: Cells treated with a NAMPT inhibitor are rescued by low NAD+ e or NAD+ precursors, depending on CD38 and CD73 expression. Conclusion: CD73 enables, whereas CD38 impairs, extracellular NMN utilization by cells for NAD+ biosynthesis. Significance: Combining CD73 and NAMPT inhibition could represent a new anti-cancer strategy.

Original language	English
Pages (from-to)	25938-25949
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.470435
Publication status	Published - Sep 6 2013

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells. / Grozio, Alessia; Sociali, Giovanna; Sturla, Laura; Caffa, Irene; Soncini, Debora; Salis, Annalisa; Raffaelli, Nadia; De Flora, Antonio; Nencioni, Alessio; Bruzzone, Santina.

In: Journal of Biological Chemistry, Vol. 288, No. 36, 06.09.2013, p. 25938-25949.

Research output: Contribution to journal › Article › peer-review

Grozio, Alessia ; Sociali, Giovanna ; Sturla, Laura ; Caffa, Irene ; Soncini, Debora ; Salis, Annalisa ; Raffaelli, Nadia ; De Flora, Antonio ; Nencioni, Alessio ; Bruzzone, Santina. / CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 36. pp. 25938-25949.

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abstract = "Background: NAMPT inhibitors showed antitumor activity in preclinical cancer models, but no tumor remission occurred in clinical studies. Results: Cells treated with a NAMPT inhibitor are rescued by low NAD+ e or NAD+ precursors, depending on CD38 and CD73 expression. Conclusion: CD73 enables, whereas CD38 impairs, extracellular NMN utilization by cells for NAD+ biosynthesis. Significance: Combining CD73 and NAMPT inhibition could represent a new anti-cancer strategy.",

author = "Alessia Grozio and Giovanna Sociali and Laura Sturla and Irene Caffa and Debora Soncini and Annalisa Salis and Nadia Raffaelli and {De Flora}, Antonio and Alessio Nencioni and Santina Bruzzone",

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AU - Caffa, Irene

AU - Soncini, Debora

AU - Salis, Annalisa

AU - Raffaelli, Nadia

AU - De Flora, Antonio

AU - Nencioni, Alessio

AU - Bruzzone, Santina

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