CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells

Alessia Grozio, Giovanna Sociali, Laura Sturla, Irene Caffa, Debora Soncini, Annalisa Salis, Nadia Raffaelli, Antonio De Flora, Alessio Nencioni, Santina Bruzzone

Research output: Contribution to journalArticle

Abstract

Background: NAMPT inhibitors showed antitumor activity in preclinical cancer models, but no tumor remission occurred in clinical studies. Results: Cells treated with a NAMPT inhibitor are rescued by low NAD+ e or NAD+ precursors, depending on CD38 and CD73 expression. Conclusion: CD73 enables, whereas CD38 impairs, extracellular NMN utilization by cells for NAD+ biosynthesis. Significance: Combining CD73 and NAMPT inhibition could represent a new anti-cancer strategy.

Original languageEnglish
Pages (from-to)25938-25949
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
Publication statusPublished - Sep 6 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Grozio, A., Sociali, G., Sturla, L., Caffa, I., Soncini, D., Salis, A., Raffaelli, N., De Flora, A., Nencioni, A., & Bruzzone, S. (2013). CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells. Journal of Biological Chemistry, 288(36), 25938-25949. https://doi.org/10.1074/jbc.M113.470435