TY - JOUR
T1 - CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells
AU - Grozio, Alessia
AU - Sociali, Giovanna
AU - Sturla, Laura
AU - Caffa, Irene
AU - Soncini, Debora
AU - Salis, Annalisa
AU - Raffaelli, Nadia
AU - De Flora, Antonio
AU - Nencioni, Alessio
AU - Bruzzone, Santina
PY - 2013/9/6
Y1 - 2013/9/6
N2 - Background: NAMPT inhibitors showed antitumor activity in preclinical cancer models, but no tumor remission occurred in clinical studies. Results: Cells treated with a NAMPT inhibitor are rescued by low NAD+ e or NAD+ precursors, depending on CD38 and CD73 expression. Conclusion: CD73 enables, whereas CD38 impairs, extracellular NMN utilization by cells for NAD+ biosynthesis. Significance: Combining CD73 and NAMPT inhibition could represent a new anti-cancer strategy.
AB - Background: NAMPT inhibitors showed antitumor activity in preclinical cancer models, but no tumor remission occurred in clinical studies. Results: Cells treated with a NAMPT inhibitor are rescued by low NAD+ e or NAD+ precursors, depending on CD38 and CD73 expression. Conclusion: CD73 enables, whereas CD38 impairs, extracellular NMN utilization by cells for NAD+ biosynthesis. Significance: Combining CD73 and NAMPT inhibition could represent a new anti-cancer strategy.
UR - http://www.scopus.com/inward/record.url?scp=84883738070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883738070&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.470435
DO - 10.1074/jbc.M113.470435
M3 - Article
C2 - 23880765
AN - SCOPUS:84883738070
VL - 288
SP - 25938
EP - 25949
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 36
ER -