CD8 lymphocyte subsets in active polymyalgia rheumatica: Comparison with elderly-onset and adult rheumatoid arthritis and influence of prednisone therapy

L. Boiardi, C. Salvarani, P. Macchioni, M. Casadei Maldini, R. Mancini, E. Beltrandi, I. Portioli

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate CD8 lymphocyte subsets in active polymyalgia rheumatica (PMR), to determine whether low percentages of CD8+ cells could be used to differentiate PMR from elderly-onset (EORA) and adult rheumatoid arthritis (RA), and to investigate the effects of prednisone on CD8 lymphocyte subsets. A significant reduction of percentages and absolute numbers of CD8bright+ cells was observed in patients with active PMR. Both CD8bright+, CD57- and CDSbright+, CD57+ subsets were significantly reduced. Reduced percentages of CD8+ cells were observed in 55% of patients with active PMR/giant cell arteritis (GCA), in 23% with EORA and in 44% with adult RA. Prednisone therapy in PMR patients, after only 1 week, increased the lymphocyte count and the absolute numbers of lymphocyte subsets significantly. However, the percentages of CD8bright+ cells remained persistently low for the 2 yr study period in 80% of the patients with low pre-treatment levels. Our results demonstrate that CD8 cell percentage is a poor epidemiological discriminator for PMR diagnosis. Notwithstanding the rise in absolute numbers of CD8 cell subsets induced by prednisone, the persistently low percentages of CD8+ cells in a group of PMR patients indicate an abnormality connected with the disease.

Original languageEnglish
Pages (from-to)642-648
Number of pages7
JournalBritish Journal of Rheumatology
Volume35
Issue number7
Publication statusPublished - 1996

Keywords

  • Adult rheumatoid arthritis
  • CD8+ cell subsets
  • Elderly-onset rheumatoid arthritis
  • Polymyalgia rheumatica
  • Prednisone

ASJC Scopus subject areas

  • Rheumatology
  • Neuroscience(all)

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