CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16

Eugenio Stabile, Timothy Kinnaird, Andrea La Sala, Sue Kim Hanson, Craig Watkins, Umberto Campia, Matie Shou, Stephan Zbinden, Shmuel Fuchs, Hardy Kornfeld, Stephen E. Epstein, Mary Susan Burnett

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND-: Previous studies have demonstrated that macrophages and CD4 T lymphocytes play pivotal roles in collateral development. Indirect evidence suggests that CD8 T cells also play a role. Thus, after acute cerebral ischemia, CD8 T cells infiltrate the perivascular space and secrete interleukin-16 (IL-16), a potent chemoattractant for monocytes and CD4 T cells. We tested whether CD8 T lymphocytes contribute to collateral vessel development and whether the lack of circulating CD8 T cells prevents IL-16 expression, impairs CD4 mononuclear cell recruitment, and reduces collateral vessel growth after femoral artery ligation in CD8 mice. METHODS AND RESULTS-: After surgical excision of the femoral artery, laser Doppler perfusion imaging demonstrated reduced blood flow recovery in CD8 mice compared with C57/BL6 mice (ischemic/nonischemic limb at day 28, 0.66±0.04 versus 0.87±0.04, respectively; P

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalCirculation
Volume113
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • Angiogenesis
  • Inflammation
  • Interleukins
  • Lymphocytes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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