TY - JOUR
T1 - CD8+CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers
AU - Filaci, Gilberto
AU - Fenoglio, Daniela
AU - Fravega, Marco
AU - Ansaldo, Gianluca
AU - Borgonovo, Giacomo
AU - Traverso, Paolo
AU - Villaggio, Barbara
AU - Ferrera, Alessandra
AU - Kunkl, Annalisa
AU - Rizzi, Marta
AU - Ferrera, Francesca
AU - Balestra, Piercesare
AU - Ghio, Massimo
AU - Contini, Paola
AU - Setti, Maurizio
AU - Olive, Daniel
AU - Azzarone, Bruno
AU - Carmignani, Giorgio
AU - Ravetti, Jean Louis
AU - Torre, Giancarlo
AU - Indiveri, Francesco
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Tumor growth is allowed by its ability to escape immune system surveillance. An important role in determining tumor evasion from immune control might be played by tumor-infiltrating regulatory lymphocytes. This study was aimed at characterizing phenotype and function of CD8+CD28 - T regulatory cells infiltrating human cancer. Lymphocytes infiltrating primitive tumor lesion and/or satellite lymph node from a series of 42 human cancers were phenotypically studied and functionally analyzed by suppressor assays. The unprecedented observation was made that CD8 +CD28- T regulatory lymphocytes are almost constantly present and functional in human tumors, being able to inhibit both T cell proliferation and cytotoxicity. CD4+CD25- T regulatory lymphocytes associate with CD8+CD28- T regulatory cells so that the immunosuppressive activity of tumor-infiltrating regulatory T cell subsets, altogether considered, may become predominant. The infiltration of regulatory T cells seems tumor related, being present in metastatic but not in metastasis-free satellite lymph nodes; it likely depends on both in situ generation (via cytokine production) and recruitment from the periphery (via chemokine secretion). Collectively, these results have pathogenic relevance and implication for immunotherapy of cancer.
AB - Tumor growth is allowed by its ability to escape immune system surveillance. An important role in determining tumor evasion from immune control might be played by tumor-infiltrating regulatory lymphocytes. This study was aimed at characterizing phenotype and function of CD8+CD28 - T regulatory cells infiltrating human cancer. Lymphocytes infiltrating primitive tumor lesion and/or satellite lymph node from a series of 42 human cancers were phenotypically studied and functionally analyzed by suppressor assays. The unprecedented observation was made that CD8 +CD28- T regulatory lymphocytes are almost constantly present and functional in human tumors, being able to inhibit both T cell proliferation and cytotoxicity. CD4+CD25- T regulatory lymphocytes associate with CD8+CD28- T regulatory cells so that the immunosuppressive activity of tumor-infiltrating regulatory T cell subsets, altogether considered, may become predominant. The infiltration of regulatory T cells seems tumor related, being present in metastatic but not in metastasis-free satellite lymph nodes; it likely depends on both in situ generation (via cytokine production) and recruitment from the periphery (via chemokine secretion). Collectively, these results have pathogenic relevance and implication for immunotherapy of cancer.
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M3 - Article
C2 - 17878327
AN - SCOPUS:38849191927
VL - 179
SP - 4323
EP - 4334
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -