CD8+ CD28- T cells in vertically HIV-infected children

D. Brugnoni, P. Airo', S. Timpano, F. Malacarne, A. G. Ugazio, R. Cattaneo, M. Duse

Research output: Contribution to journalArticlepeer-review


To evaluate whether vertical HIV infection interferes with the expression of CD28 on T lymphocytes, 25 HIV-infected children and 29 seroreverted children born to HIV+ mothers were studied. The percentage of CD28- cells among CD8+T lymphocytes was higher in HIV-infected children than in controls (P <0.001). In fact, in HIV-infected children, this percentage was elevated from the first year of life, while in healthy seroreverted children, the proportion of CD28- cells among CD8+ cells rose progressively with age (r = 0.49; P = 0.008). In HIV+ children, the CD8+ CD28-, but not CD8+ CD28+ cell proportion was significantly correlated with immunological markers of disease progression, such as CD4+ cell loss (r=-0.65; P

Original languageEnglish
Pages (from-to)412-415
Number of pages4
JournalClinical and Experimental Immunology
Issue number3
Publication statusPublished - 1997


  • Apoptosis
  • CD28T cells
  • HIV children

ASJC Scopus subject areas

  • Immunology


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