CD8+ CD28- T cells in vertically HIV-infected children

D. Brugnoni, P. Airo', S. Timpano, F. Malacarne, A. G. Ugazio, R. Cattaneo, M. Duse

Research output: Contribution to journalArticle

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Abstract

To evaluate whether vertical HIV infection interferes with the expression of CD28 on T lymphocytes, 25 HIV-infected children and 29 seroreverted children born to HIV+ mothers were studied. The percentage of CD28- cells among CD8+T lymphocytes was higher in HIV-infected children than in controls (P <0.001). In fact, in HIV-infected children, this percentage was elevated from the first year of life, while in healthy seroreverted children, the proportion of CD28- cells among CD8+ cells rose progressively with age (r = 0.49; P = 0.008). In HIV+ children, the CD8+ CD28-, but not CD8+ CD28+ cell proportion was significantly correlated with immunological markers of disease progression, such as CD4+ cell loss (r=-0.65; P

Original languageEnglish
Pages (from-to)412-415
Number of pages4
JournalClinical and Experimental Immunology
Volume109
Issue number3
Publication statusPublished - 1997

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HIV
T-Lymphocytes
Immune System Diseases
HIV Infections
Disease Progression
Mothers

Keywords

  • Apoptosis
  • CD28T cells
  • HIV children

ASJC Scopus subject areas

  • Immunology

Cite this

Brugnoni, D., Airo', P., Timpano, S., Malacarne, F., Ugazio, A. G., Cattaneo, R., & Duse, M. (1997). CD8+ CD28- T cells in vertically HIV-infected children. Clinical and Experimental Immunology, 109(3), 412-415.

CD8+ CD28- T cells in vertically HIV-infected children. / Brugnoni, D.; Airo', P.; Timpano, S.; Malacarne, F.; Ugazio, A. G.; Cattaneo, R.; Duse, M.

In: Clinical and Experimental Immunology, Vol. 109, No. 3, 1997, p. 412-415.

Research output: Contribution to journalArticle

Brugnoni, D, Airo', P, Timpano, S, Malacarne, F, Ugazio, AG, Cattaneo, R & Duse, M 1997, 'CD8+ CD28- T cells in vertically HIV-infected children', Clinical and Experimental Immunology, vol. 109, no. 3, pp. 412-415.
Brugnoni D, Airo' P, Timpano S, Malacarne F, Ugazio AG, Cattaneo R et al. CD8+ CD28- T cells in vertically HIV-infected children. Clinical and Experimental Immunology. 1997;109(3):412-415.
Brugnoni, D. ; Airo', P. ; Timpano, S. ; Malacarne, F. ; Ugazio, A. G. ; Cattaneo, R. ; Duse, M. / CD8+ CD28- T cells in vertically HIV-infected children. In: Clinical and Experimental Immunology. 1997 ; Vol. 109, No. 3. pp. 412-415.
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