CD8+ T regulatory/suppressor cells and their relationships with autoreactivity and autoimmunity

Gilberto Filaci, Daniela Fenoglio, Francesco Indiveri

Research output: Contribution to journalArticle

Abstract

Regulatory T lymphocytes (Treg) are fundamental for immune homeostasis since they contribute to the induction of peripheral tolerance to autologous antigens and regulate effector immune responses. Treg subsets are present within both the CD4and the CD8+ T cell compartments. Considering the CD8+ Treg, in the last decades several subpopulations, provided with different phenotypes and mechanisms of action, have been characterized. This review is an attempt of integrating in an organic scenario the different CD8+ Treg subpopulations. Moreover, it summarizes the findings so far achieved on the existence of CD8+ Treg alterations in autoimmune diseases.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalAutoimmunity
Volume44
Issue number1
DOIs
Publication statusPublished - Feb 2011

    Fingerprint

Keywords

  • Autoimmunity
  • CD8 Treg
  • IL10
  • TGFβ
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this