CD90/Thy-1 is preferentially expressed on blast cells of high risk acute myeloid leukaemias

Francesco Buccisano, Francesca Maria Rossi, Adriano Venditti, Giovanni Del Poeta, Maria Christina Cox, Elisabetta Abbruzzese, Maurizio Rupolo, Massimiliano Berretta, Massimo Degan, Stefania Russo, Anna Tamburini, Luca Maurillo, Maria Ilaria Del Principe, Massimiliano Postorino, Sergio Amadori, Valter Gattei

Research output: Contribution to journalArticle

Abstract

Different transformation mechanisms have been proposed for elderly acute myeloid leukaemia (AML) and secondary AML (sAML) when compared with de novo AML or AML of younger patients. However, little is known regarding differences in the immunophenotypic profile of blast cells in these diseases. We systematically analysed, by flow cytometry, 148 patients affected by de novo (100 cases) or sAML (48 cases). By defining a cut-off level of 20% of CD34+ cells co-expressing CD90, the frequency of CD90+ cases was higher in sAML (40%) versus de novo AML (6%, P <0.001), elderly AML (>60 years) (24%) versus AML of younger patients (10%, P = 0.010) and poor- versus good-risk karyotypes (according to the Medical Research Council classification, P <0.001). The correlation between CD90 expression, sAML and unfavourable karyotypes was confirmed by analysing the subset of CD34+ AML cases alone (91/148). Consistently, univariate analysis showed that expression of CD90 was statistically relevant in predicting a shorter survival in CD90+ AML patients (P = 0.042). Our results, demonstrating CD90 expression in AML with unfavourable clinical and biological features, suggest an origin of these diseases from a CD90-expressing haemopoietic progenitor and indicate the use of CD90 as an additional marker of prognostic value in AML.

Original languageEnglish
Pages (from-to)203-212
Number of pages10
JournalBritish Journal of Haematology
Volume125
Issue number2
DOIs
Publication statusPublished - Apr 2004

Keywords

  • CD90/Thy1
  • Poor-risk cytogenetics
  • Secondary AML

ASJC Scopus subject areas

  • Hematology

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    Buccisano, F., Rossi, F. M., Venditti, A., Del Poeta, G., Cox, M. C., Abbruzzese, E., Rupolo, M., Berretta, M., Degan, M., Russo, S., Tamburini, A., Maurillo, L., Del Principe, M. I., Postorino, M., Amadori, S., & Gattei, V. (2004). CD90/Thy-1 is preferentially expressed on blast cells of high risk acute myeloid leukaemias. British Journal of Haematology, 125(2), 203-212. https://doi.org/10.1111/j.1365-2141.2004.04883.x