Abstract
CD95 (Fas/Apo-1) is a broadly expressed death receptor involved in a variety of physiological and pathological apoptotic processes. Since its discovery, defects in CD95/CD95L system have been proposed as major pathogenic factors responsible for impaired immunological tolerance to self antigens and autoimmunity. Later, analysis of altered sensitivity to CD95-induced apoptosis in cells targeted by the immune response has revealed an unexpected role for CD95 and CD95L in organ-specific autoimmunity. CD95 has been shown to be expressed and functional in virtually all cell types that are target of the organ-specific autoimmune response. Here we review some of the major findings concerning the role of CD95 in autoimmunity, in dysfunctions due to increased or decreased CD95-induced apoptosis.
Original language | English |
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Pages (from-to) | 419-424 |
Number of pages | 6 |
Journal | Apoptosis |
Volume | 5 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- Apoptosis
- Diabetes
- Fas
- Organ-specific autoimmunity
- Thyroiditis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology