CD95/CD95L interactions and their role in autoimmunity

L. Ricci-Vitiani, C. Conticello, A. Zeuner, R. De Maria

Research output: Contribution to journalArticlepeer-review


CD95 (Fas/Apo-1) is a broadly expressed death receptor involved in a variety of physiological and pathological apoptotic processes. Since its discovery, defects in CD95/CD95L system have been proposed as major pathogenic factors responsible for impaired immunological tolerance to self antigens and autoimmunity. Later, analysis of altered sensitivity to CD95-induced apoptosis in cells targeted by the immune response has revealed an unexpected role for CD95 and CD95L in organ-specific autoimmunity. CD95 has been shown to be expressed and functional in virtually all cell types that are target of the organ-specific autoimmune response. Here we review some of the major findings concerning the role of CD95 in autoimmunity, in dysfunctions due to increased or decreased CD95-induced apoptosis.

Original languageEnglish
Pages (from-to)419-424
Number of pages6
Issue number5
Publication statusPublished - 2000


  • Apoptosis
  • Diabetes
  • Fas
  • Organ-specific autoimmunity
  • Thyroiditis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology


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