CDC20 and CDH1: A family of substrate-specific activators of APC- dependent proteolysis

Rosella Visintin, Susanne Prinz, Angelika Amon

Research output: Contribution to journalArticle

Abstract

Proteolysis mediated by the anaphase-promoting complex (APC) triggers chromosome segregation and exit from mitosis, yet its regulation is poorly understood. The conserved CDC20 and Cdh1 proteins were identified as limiting, substrate-specific activators of APC-dependent proteolysis. CDC20 was required for the degradation of the APC substrate Pds1 but not for that of other APC substrates, such as Clb2 and Ase1. Conversely, cdh1Δ mutants were impaired in the degradation of Ase1 and Clb2 but not in that of Pds1. Overexpression of either CDC20 or CDH1 was sufficient to induce APC-dependent proteolysis of the appropriate target in stages of the cell cycle in which substrates are normally stable.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalScience
Volume278
Issue number5337
DOIs
Publication statusPublished - Oct 17 1997

ASJC Scopus subject areas

  • General

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