Cdc42 is involved in basal cell carcinoma carcinogenesis

Maria Giovanna Tucci, Guendalina Lucarini, Antonio Zizzi, Romina Rocchetti, Donatella Brancorsini, Roberto Di Primio, Francesca Ricotti, Giuseppe Ricotti

Research output: Contribution to journalArticlepeer-review


Basal cell carcinoma (BCC) is the most common type of skin cancer in older persons and is a rapidly rising incidence. E-cadherin-mediated cell-cell adhesion activates Cdc42, a Rho GTPase essential for cell polarity in numerous settings. No study has yet addressed a biological significance of Cdc42 alterations in BCC pathogenesis. Our aim was to investigate E-cadherin-dependent cell-cell contacts and Cdc42 activity in BCC formation. We evaluated E-cadherin and Cdc42 expression by immunohistochemistry and Western blot analysis in samples of 15 normal skin (NS) and 30 BCC (10 superficial, 9 nodular and 11 infiltrative subtypes). Low E-cadherin and high Cdc42 immunohistochemical expression were found in BCC samples compared with NS. E-cadherin staining was significantly reduced in infiltrative BCC compared with superficial and nodular. A significantly greater Cdc42 expression was observed in BCC compared with NS; moreover, superficial BCC had a significantly lower Cdc42 expression in respect to the other subtypes. Western blot analysis confirmed the significantly decreased E-cadherin expression in infiltrative BCC as well as Cdc42 reduction in superficial BCC in respect to the other subtypes. In BCC the increased Cdc42 in association with reduced E-cadherin might contribute to the disruption of adhesion mechanisms and to the loss of cell polarity, thus explaining a mechanism by which cancer cells can escape from the control of adjacent normal keratinocytes. Our study also showed that Cdc42 and E-cadherin expression differed according to aggressive behaviour of BCC subtypes and suggested important functions of these molecules in regulating tumour demarcation and progression.

Original languageEnglish
Pages (from-to)835-840
Number of pages6
JournalArchives of Dermatological Research
Issue number9
Publication statusPublished - Nov 2013


  • Basal cell carcinoma
  • Cdc42
  • Cell polarity
  • E-cadherin

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Cdc42 is involved in basal cell carcinoma carcinogenesis'. Together they form a unique fingerprint.

Cite this