CDH1 C-160A promoter polymorphism and gastric cancer risk

Giovanni Corso, Anna Berardi, Daniele Marrelli, Corrado Pedrazzani, Lorenzo Garosi, Enrico Pinto, Franco Roviello

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to find out whether C-160A single nucleotide polymorphism of the promoter region of the E-cadherin gene might be a potential genetic marker for identifying individuals at risk for gastric cancer (GC). To test this hypothesis, 412 GC patients and 408 controls were analyzed statistically. A PCR-restriction fragment length polymorphism assay was adopted for C-160A single nucleotide polymorphism detection. No statistical differences were found among CC, CA, and AA genotypes and the risk of GC, even stratifying according to age, sex, and area of residence. Similarly, genotype was not associated with intestinal or diffuse histotypes, or with cardia or noncardia carcinomas. In conclusion, the C-160A polymorphism is not associated with GC risk in the Italian population. European Journal of Cancer Prevention 18:46-49

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalEuropean Journal of Cancer Prevention
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2009

Keywords

  • E-cadherin
  • Gastric cancer
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

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