CDH1 C-160A promoter polymorphism and gastric cancer risk

Giovanni Corso, Anna Berardi, Daniele Marrelli, Corrado Pedrazzani, Lorenzo Garosi, Enrico Pinto, Franco Roviello

Research output: Contribution to journalArticle

Abstract

The objective of this study was to find out whether C-160A single nucleotide polymorphism of the promoter region of the E-cadherin gene might be a potential genetic marker for identifying individuals at risk for gastric cancer (GC). To test this hypothesis, 412 GC patients and 408 controls were analyzed statistically. A PCR-restriction fragment length polymorphism assay was adopted for C-160A single nucleotide polymorphism detection. No statistical differences were found among CC, CA, and AA genotypes and the risk of GC, even stratifying according to age, sex, and area of residence. Similarly, genotype was not associated with intestinal or diffuse histotypes, or with cardia or noncardia carcinomas. In conclusion, the C-160A polymorphism is not associated with GC risk in the Italian population. European Journal of Cancer Prevention 18:46-49

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalEuropean Journal of Cancer Prevention
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Stomach Neoplasms
Single Nucleotide Polymorphism
Genotype
Cardia
Cadherins
Genetic Markers
Genetic Promoter Regions
Restriction Fragment Length Polymorphisms
Carcinoma
Polymerase Chain Reaction
Population
Genes
Neoplasms

Keywords

  • E-cadherin
  • Gastric cancer
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Corso, G., Berardi, A., Marrelli, D., Pedrazzani, C., Garosi, L., Pinto, E., & Roviello, F. (2009). CDH1 C-160A promoter polymorphism and gastric cancer risk. European Journal of Cancer Prevention, 18(1), 46-49. https://doi.org/10.1097/CEJ.0b013e32830c8d70

CDH1 C-160A promoter polymorphism and gastric cancer risk. / Corso, Giovanni; Berardi, Anna; Marrelli, Daniele; Pedrazzani, Corrado; Garosi, Lorenzo; Pinto, Enrico; Roviello, Franco.

In: European Journal of Cancer Prevention, Vol. 18, No. 1, 02.2009, p. 46-49.

Research output: Contribution to journalArticle

Corso, G, Berardi, A, Marrelli, D, Pedrazzani, C, Garosi, L, Pinto, E & Roviello, F 2009, 'CDH1 C-160A promoter polymorphism and gastric cancer risk', European Journal of Cancer Prevention, vol. 18, no. 1, pp. 46-49. https://doi.org/10.1097/CEJ.0b013e32830c8d70
Corso, Giovanni ; Berardi, Anna ; Marrelli, Daniele ; Pedrazzani, Corrado ; Garosi, Lorenzo ; Pinto, Enrico ; Roviello, Franco. / CDH1 C-160A promoter polymorphism and gastric cancer risk. In: European Journal of Cancer Prevention. 2009 ; Vol. 18, No. 1. pp. 46-49.
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