CDKN2A is the main susceptibility gene in Italian pancreatic cancer families

Paola Ghiorzo, Giuseppe Fornarini, Stefania Sciallero, Linda Battistuzzi, Fiorenza Belli, Loris Bernard, Luigina Bonelli, Giacomo Borgonovo, William Bruno, Franco De Cian, Andrea Decensi, Marco Filauro, Francesca Faravelli, Alberto Gozza, Sara Gargiulo, Frederique Mariette, Sabina Nasti, Lorenza Pastorino, Paola Queirolo, Vincenzo SavarinoLiliana Varesco, Giovanna Bianchi Scarrà

Research output: Contribution to journalArticlepeer-review


Background: Most familial pancreatic cancer (FPC) remains unexplained. The identification of individuals with a high genetic risk of developing pancreatic adenocarcinoma (PC) is important to elucidate its biological basis and is critical to better define emerging strategies for the detection of early pancreatic neoplasms. Patients and methods: A series of 225 consecutively enrolled patients with PC were tested for CDKN2A mutations. After personal and family cancer histories of all the patients had been reviewed, a subset of the patients were classified as FPC and were also tested for mutations in PALLD, PALB2, BRCA1 and BRCA2 as FPC candidate genes. Results: The CDKN2A mutation rate in the 225 PC cases was 5.7%. The CDKN2A founder mutations, p.E27X and p.G101W, were predominant, but the mutation spectrum also included p.L65P, p.G67R and two novel, potentially pathogenic variants, promoter variant c.-201ACTC>CTTT and p.R144C. None of the patients with FPC harboured germline mutations in PALLD, PALB2 or BRCA2. One family was positive for the BRCA1 UV variant p.P727L. Strikingly, five of 16 patients with FPC (31%) carried CDKN2A mutations. Conclusion These findings suggest that a sizeable subset of Italian FPC families may carry CDKN2A mutations. This result may be of value for identifying the best candidates for future PC screening trials in Italy.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalJournal of Medical Genetics
Issue number3
Publication statusPublished - Mar 2012

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


Dive into the research topics of 'CDKN2A is the main susceptibility gene in Italian pancreatic cancer families'. Together they form a unique fingerprint.

Cite this