cDNA characterization and chromosome mapping of the human Gas2 gene

Licio Collavin, Monica Buzzai, Salvatore Saccone, Loris Bernard, Concetta Federico, Giuliano DellaValle, Claudio Brancolini, Claudio Schneider

Research output: Contribution to journalArticlepeer-review


Murine Gas2 is a microfilament-associated protein whose expression is increased at growth arrest in mammalian cells. During apoptosis, Gas2 is specifically cleaved at its C-terminus by a still unknown ICE-like protease, and the processed protein induces dramatic rearrangements in the cytoskeleton when over-expressed in several cell types. Here we report the characterization of a cDNA encoding the human homologue of Gas2, showing high conservation with the murine counterpart at the protein level. Fluorescence in situ hybridization analysis and radiation hybrid mapping localized the GAS2 gene on human chromosome 11p14.3-p15.2, in a region homologous to the gas2 region on mouse chromosome 7.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
Issue number2
Publication statusPublished - Mar 1 1998

ASJC Scopus subject areas

  • Genetics


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