Abstract
On the basis of the analysis of cDNA of three new homeobox-containing genes from human, chicken and newt, a new class of homebox genes Anf is characterized homologous to the Xanf-1 gene from Xenopus laevis, earlier cloned by us. These genes may be largely involved in the specification of embryonic subdivisions in the forebrain region of the embryo. The homeodomains of the proteins encoded by these genes differ greatly in the primary structure from all previously described homeobox genes. The high variability of the homeodomain sequences of the proteins of this class imply their rapid evolution.
| Original language | English |
|---|---|
| Pages (from-to) | 192-193 |
| Number of pages | 2 |
| Journal | Bioorganicheskaya Khimiya |
| Volume | 24 |
| Issue number | 3 |
| Publication status | Published - Mar 1998 |
Keywords
- Cloning
- Forebrain
- Homeobox-containing genes
- PCR
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Organic Chemistry
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Kazanskaya, O. V., Ermakova, G. V., Pannese, M., Boncinelli, E., & Zaraisky, A. G. (1998). cDNA Cloning of Three New Homeobox-Containing Genes of the Anf Class from Human, Chicken, and Newt. Bioorganicheskaya Khimiya, 24(3), 192-193.