cDNA cloning of three new homeobox-containing genes of the Anf class from human, chicken, and newt

O. V. Kazanskaya, G. V. Ermakova, M. Pannese, S. A. Lukyanov, E. Boncinelli, A. G. Zaraisky

Research output: Contribution to journalArticle

Abstract

On the basis of the analysis of the cDNA of three new homeobox-containing genes from human, chicken, and newt, a new class of homeobox genes Anf is characterized homologous to the Xanf-1 gene from Xenopus laevis, earlier cloned by us. These genes may be largely involved in the specification of embryonic subdivisions in the forebrain region of the embryo. The homeodomains of the proteins encoded by these genes differ greatly in primary structure from all previously described homeobox genes. The high variability of the homeodomain sequences of the proteins of this class imply their rapid evolution.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalRussian Journal of Bioorganic Chemistry
Volume24
Issue number3
Publication statusPublished - 1998

Keywords

  • Cloning
  • Forebrain
  • Homeobox-containing genes
  • PCR

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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    Kazanskaya, O. V., Ermakova, G. V., Pannese, M., Lukyanov, S. A., Boncinelli, E., & Zaraisky, A. G. (1998). cDNA cloning of three new homeobox-containing genes of the Anf class from human, chicken, and newt. Russian Journal of Bioorganic Chemistry, 24(3), 166-172.