cDNA cloning of turtle prion protein

Tatjana Simonic, Stefano Duga, Bice Strumbo, Rosanna Asselta, Fabrizio Ceciliani, Severino Ronchi

Research output: Contribution to journalArticlepeer-review

Abstract

Cloning of the cDNA coding for the 270-residue turtle prion protein is reported. It represents the most remote example thus far described. The entire coding region is comprised in a single exon, while a large intron interrupts the 5' UTR. The common structural features of the known prion proteins are all conserved in turtle PrP, whose identity degree to mammalian and avian proteins is about 40 and 58%, respectively. The most intriguing feature, unique to the turtle prion, is the presence of an EF-hand Ca2+ binding motif in the C-terminal half of the protein. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalFEBS Letters
Volume469
Issue number1
DOIs
Publication statusPublished - Mar 3 2000

Keywords

  • cDNA cloning
  • EF-hand Ca binding motif
  • Gene organization
  • Reptile prion protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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