TY - JOUR
T1 - cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes
AU - Lania, Luigi
AU - Donti, Emilio
AU - Pannuti, Antonio
AU - Pascucci, Anna
AU - Pengue, Gina
AU - Feliciello, Isidoro
AU - La Mantia, Girolama
AU - Lanfrancone, Luisa
AU - Pelicci, Pier Giuseppe
PY - 1990
Y1 - 1990
N2 - On the basis of sequence similarity in the repeated zinc finger domain, we have identified and characterized two human cDNA clones (ZNF7 and ZNF8), both encoding proteins containing potential finger-like nucleic acid binding motifs. Northern blot analysis indicates that both genes are expressed as multiple transcripts and they are ubiquitously present in many human cell lines of different embryological derivation. Moreover, their expression is modulated during in vitro induced terminal differentiation of human myeloid cell line HL-60. By in situ hybridization experiments, we have localized the ZNF7 gene to chromosome 8 (region q24) and the ZNF8 gene to the terminal band of the long arm of chromosome 20 (20q13).
AB - On the basis of sequence similarity in the repeated zinc finger domain, we have identified and characterized two human cDNA clones (ZNF7 and ZNF8), both encoding proteins containing potential finger-like nucleic acid binding motifs. Northern blot analysis indicates that both genes are expressed as multiple transcripts and they are ubiquitously present in many human cell lines of different embryological derivation. Moreover, their expression is modulated during in vitro induced terminal differentiation of human myeloid cell line HL-60. By in situ hybridization experiments, we have localized the ZNF7 gene to chromosome 8 (region q24) and the ZNF8 gene to the terminal band of the long arm of chromosome 20 (20q13).
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U2 - 10.1016/0888-7543(90)90574-E
DO - 10.1016/0888-7543(90)90574-E
M3 - Article
C2 - 2106481
AN - SCOPUS:0025322510
VL - 6
SP - 333
EP - 340
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -