Abstract
DNA mismatch repair genes (MMR) have been actively studied in humans for their role in cancer susceptibility. Recently, GTBP, a new member of the MMR gene family, has been cloned and found to encode a 160-kDa protein that forms a heterodimer with hMSH2. Our group has isolated and characterized the mouse homolog of GTBP. The transcript, termed Gtmbp (G/T mismatch-binding protein), encodes a protein highly similar to its human counterpart. The gene is markedly conserved across species and maps to the distal portion of mouse chromosome 17, in a region homologous to human 2p. One Gtmbp-related sequence maps to proximal mouse chromosome 4. Studies of the expression of Gtmbp suggest that its regulated transcription is tightly linked to the level of DNA replication, consistent with the protein's DNA proofreading function.
| Original language | English |
|---|---|
| Pages (from-to) | 288-295 |
| Number of pages | 8 |
| Journal | Genomics |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Sep 1 1996 |
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ASJC Scopus subject areas
- Genetics
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cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene. / Corradi, A.; Croci, L.; Stayton, C. L.; Gulisano, M.; Boncinelli, E.; Consalez, G. G.
In: Genomics, Vol. 36, No. 2, 01.09.1996, p. 288-295.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene
AU - Corradi, A.
AU - Croci, L.
AU - Stayton, C. L.
AU - Gulisano, M.
AU - Boncinelli, E.
AU - Consalez, G. G.
PY - 1996/9/1
Y1 - 1996/9/1
N2 - DNA mismatch repair genes (MMR) have been actively studied in humans for their role in cancer susceptibility. Recently, GTBP, a new member of the MMR gene family, has been cloned and found to encode a 160-kDa protein that forms a heterodimer with hMSH2. Our group has isolated and characterized the mouse homolog of GTBP. The transcript, termed Gtmbp (G/T mismatch-binding protein), encodes a protein highly similar to its human counterpart. The gene is markedly conserved across species and maps to the distal portion of mouse chromosome 17, in a region homologous to human 2p. One Gtmbp-related sequence maps to proximal mouse chromosome 4. Studies of the expression of Gtmbp suggest that its regulated transcription is tightly linked to the level of DNA replication, consistent with the protein's DNA proofreading function.
AB - DNA mismatch repair genes (MMR) have been actively studied in humans for their role in cancer susceptibility. Recently, GTBP, a new member of the MMR gene family, has been cloned and found to encode a 160-kDa protein that forms a heterodimer with hMSH2. Our group has isolated and characterized the mouse homolog of GTBP. The transcript, termed Gtmbp (G/T mismatch-binding protein), encodes a protein highly similar to its human counterpart. The gene is markedly conserved across species and maps to the distal portion of mouse chromosome 17, in a region homologous to human 2p. One Gtmbp-related sequence maps to proximal mouse chromosome 4. Studies of the expression of Gtmbp suggest that its regulated transcription is tightly linked to the level of DNA replication, consistent with the protein's DNA proofreading function.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030249191&partnerID=8YFLogxK
U2 - 10.1006/geno.1996.0464
DO - 10.1006/geno.1996.0464
M3 - Article
C2 - 8812455
AN - SCOPUS:0030249191
VL - 36
SP - 288
EP - 295
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -