cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene

A. Corradi, L. Croci, C. L. Stayton, M. Gulisano, E. Boncinelli, G. G. Consalez

Research output: Contribution to journalArticle

Abstract

DNA mismatch repair genes (MMR) have been actively studied in humans for their role in cancer susceptibility. Recently, GTBP, a new member of the MMR gene family, has been cloned and found to encode a 160-kDa protein that forms a heterodimer with hMSH2. Our group has isolated and characterized the mouse homolog of GTBP. The transcript, termed Gtmbp (G/T mismatch-binding protein), encodes a protein highly similar to its human counterpart. The gene is markedly conserved across species and maps to the distal portion of mouse chromosome 17, in a region homologous to human 2p. One Gtmbp-related sequence maps to proximal mouse chromosome 4. Studies of the expression of Gtmbp suggest that its regulated transcription is tightly linked to the level of DNA replication, consistent with the protein's DNA proofreading function.

Original languageEnglish
Pages (from-to)288-295
Number of pages8
JournalGenomics
Volume36
Issue number2
DOIs
Publication statusPublished - Sep 1 1996

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DNA Mismatch Repair
Complementary DNA
Genes
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 4
Proteins
DNA Replication
DNA
G-T mismatch-binding protein
Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene. / Corradi, A.; Croci, L.; Stayton, C. L.; Gulisano, M.; Boncinelli, E.; Consalez, G. G.

In: Genomics, Vol. 36, No. 2, 01.09.1996, p. 288-295.

Research output: Contribution to journalArticle

Corradi, A, Croci, L, Stayton, CL, Gulisano, M, Boncinelli, E & Consalez, GG 1996, 'cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene', Genomics, vol. 36, no. 2, pp. 288-295. https://doi.org/10.1006/geno.1996.0464
Corradi, A. ; Croci, L. ; Stayton, C. L. ; Gulisano, M. ; Boncinelli, E. ; Consalez, G. G. / cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene. In: Genomics. 1996 ; Vol. 36, No. 2. pp. 288-295.
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