Abstract
C/EBPβ is a leucine-zipper transcription factor believed to play an important role in the control of liver functions, and in particular in the transcriptional regulation of acute phase genes in response to several inflammatory stimuli and to recombinant cytokines. Moreover, this factor has been proposed as an important activator of several cytokine genes. We recently described the generation of mice in which the C/EBPβ gene has been inactivated by gene targeting, showing that they are viable, but present specific defects in the myeloid and lymphoid compartments. Here we demonstrate that C/EBPβ does indeed play a role in the transcriptional induction of some, but not all, liver acute phase genes. Activation is in particular defective in C/EBPβ-deficient mice in the later phases of induction, suggesting that the early phases may be triggered by factors other than C/EBPs. Moreover, IL-6 activation is normal and TNFα activation is defective in the mutant mice, indicating a differential role of C/EBPβ in the control of these two cytokines' production.
| Original language | English |
|---|---|
| Pages (from-to) | 29-35 |
| Number of pages | 7 |
| Journal | Cell Death and Differentiation |
| Volume | 3 |
| Issue number | 1 |
| Publication status | Published - 1996 |
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Keywords
- C/EBP proteins
- Gene targeting
- Inflammation
- Liver acute phase response
- Transcriptional induction
ASJC Scopus subject areas
- Cell Biology
Cite this
C/EBPβ is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-α, but not interleukin-6, regulation. / Cappelletti, M.; Alonzi, T.; Fattori, E.; Libert, C.; Poli, V.
In: Cell Death and Differentiation, Vol. 3, No. 1, 1996, p. 29-35.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C/EBPβ is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-α, but not interleukin-6, regulation
AU - Cappelletti, M.
AU - Alonzi, T.
AU - Fattori, E.
AU - Libert, C.
AU - Poli, V.
PY - 1996
Y1 - 1996
N2 - C/EBPβ is a leucine-zipper transcription factor believed to play an important role in the control of liver functions, and in particular in the transcriptional regulation of acute phase genes in response to several inflammatory stimuli and to recombinant cytokines. Moreover, this factor has been proposed as an important activator of several cytokine genes. We recently described the generation of mice in which the C/EBPβ gene has been inactivated by gene targeting, showing that they are viable, but present specific defects in the myeloid and lymphoid compartments. Here we demonstrate that C/EBPβ does indeed play a role in the transcriptional induction of some, but not all, liver acute phase genes. Activation is in particular defective in C/EBPβ-deficient mice in the later phases of induction, suggesting that the early phases may be triggered by factors other than C/EBPs. Moreover, IL-6 activation is normal and TNFα activation is defective in the mutant mice, indicating a differential role of C/EBPβ in the control of these two cytokines' production.
AB - C/EBPβ is a leucine-zipper transcription factor believed to play an important role in the control of liver functions, and in particular in the transcriptional regulation of acute phase genes in response to several inflammatory stimuli and to recombinant cytokines. Moreover, this factor has been proposed as an important activator of several cytokine genes. We recently described the generation of mice in which the C/EBPβ gene has been inactivated by gene targeting, showing that they are viable, but present specific defects in the myeloid and lymphoid compartments. Here we demonstrate that C/EBPβ does indeed play a role in the transcriptional induction of some, but not all, liver acute phase genes. Activation is in particular defective in C/EBPβ-deficient mice in the later phases of induction, suggesting that the early phases may be triggered by factors other than C/EBPs. Moreover, IL-6 activation is normal and TNFα activation is defective in the mutant mice, indicating a differential role of C/EBPβ in the control of these two cytokines' production.
KW - C/EBP proteins
KW - Gene targeting
KW - Inflammation
KW - Liver acute phase response
KW - Transcriptional induction
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M3 - Article
C2 - 17180052
AN - SCOPUS:0029671351
VL - 3
SP - 29
EP - 35
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
SN - 1350-9047
IS - 1
ER -