Ceftobiprole: drug evaluation and place in therapy

Daniele Roberto Giacobbe, Francesco Giuseppe De Rosa, Valerio Del Bono, Paolo Antonio Grossi, Federico Pea, Nicola Petrosillo, Gian Maria Rossolini, Carlo Tascini, Mario Tumbarello, Pierluigi Viale, Matteo Bassetti

Research output: Contribution to journalArticle

Abstract

Introduction: Ceftobiprole is a fifth-generation cephalosporin with a broad spectrum of antimicrobial activity, including also methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole is approved for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), excluding ventilator-associated pneumonia, in several European and non-European countries. Areas covered: In this narrative review, we discuss the current place in therapy of ceftobiprole, both within and outside approved indications. An inductive MEDLINE/PubMed search of the available literature was conducted. Expert opinion: There are three main reasons which render ceftobiprole an attractive option for the empirical and targeted treatment of CAP and HAP: (i) its broad spectrum of activity; (ii) its activity against MRSA; (iii) its good safety profile. For these indications, ceftobiprole should be employed thoughtfully, in those scenarios in which its intrinsic advantages could be maximized. The use of ceftobiprole outside approved indications could be justified in specific scenarios, such as when other approved alternatives are ineffective, when the risk of toxicity due to other agents is unacceptable, and for salvage therapy. In the near future, ongoing phase 3 studies and further observational experiences could both enlarge the current panel of approved indications and enrich our knowledge on the use of ceftobiprole for off-label indications.

Original languageEnglish
Pages (from-to)689-698
Number of pages10
JournalExpert Review of Anti-Infective Therapy
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 1 2019

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Keywords

  • CAP
  • Ceftobiprole
  • HAP
  • MRSA

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

Giacobbe, D. R., De Rosa, F. G., Del Bono, V., Grossi, P. A., Pea, F., Petrosillo, N., Rossolini, G. M., Tascini, C., Tumbarello, M., Viale, P., & Bassetti, M. (2019). Ceftobiprole: drug evaluation and place in therapy. Expert Review of Anti-Infective Therapy, 17(9), 689-698. https://doi.org/10.1080/14787210.2019.1667229