TY - JOUR
T1 - Ceftobiprole
T2 - drug evaluation and place in therapy
AU - Giacobbe, Daniele Roberto
AU - De Rosa, Francesco Giuseppe
AU - Del Bono, Valerio
AU - Grossi, Paolo Antonio
AU - Pea, Federico
AU - Petrosillo, Nicola
AU - Rossolini, Gian Maria
AU - Tascini, Carlo
AU - Tumbarello, Mario
AU - Viale, Pierluigi
AU - Bassetti, Matteo
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Introduction: Ceftobiprole is a fifth-generation cephalosporin with a broad spectrum of antimicrobial activity, including also methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole is approved for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), excluding ventilator-associated pneumonia, in several European and non-European countries. Areas covered: In this narrative review, we discuss the current place in therapy of ceftobiprole, both within and outside approved indications. An inductive MEDLINE/PubMed search of the available literature was conducted. Expert opinion: There are three main reasons which render ceftobiprole an attractive option for the empirical and targeted treatment of CAP and HAP: (i) its broad spectrum of activity; (ii) its activity against MRSA; (iii) its good safety profile. For these indications, ceftobiprole should be employed thoughtfully, in those scenarios in which its intrinsic advantages could be maximized. The use of ceftobiprole outside approved indications could be justified in specific scenarios, such as when other approved alternatives are ineffective, when the risk of toxicity due to other agents is unacceptable, and for salvage therapy. In the near future, ongoing phase 3 studies and further observational experiences could both enlarge the current panel of approved indications and enrich our knowledge on the use of ceftobiprole for off-label indications.
AB - Introduction: Ceftobiprole is a fifth-generation cephalosporin with a broad spectrum of antimicrobial activity, including also methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole is approved for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), excluding ventilator-associated pneumonia, in several European and non-European countries. Areas covered: In this narrative review, we discuss the current place in therapy of ceftobiprole, both within and outside approved indications. An inductive MEDLINE/PubMed search of the available literature was conducted. Expert opinion: There are three main reasons which render ceftobiprole an attractive option for the empirical and targeted treatment of CAP and HAP: (i) its broad spectrum of activity; (ii) its activity against MRSA; (iii) its good safety profile. For these indications, ceftobiprole should be employed thoughtfully, in those scenarios in which its intrinsic advantages could be maximized. The use of ceftobiprole outside approved indications could be justified in specific scenarios, such as when other approved alternatives are ineffective, when the risk of toxicity due to other agents is unacceptable, and for salvage therapy. In the near future, ongoing phase 3 studies and further observational experiences could both enlarge the current panel of approved indications and enrich our knowledge on the use of ceftobiprole for off-label indications.
KW - CAP
KW - Ceftobiprole
KW - HAP
KW - MRSA
UR - http://www.scopus.com/inward/record.url?scp=85072746435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072746435&partnerID=8YFLogxK
U2 - 10.1080/14787210.2019.1667229
DO - 10.1080/14787210.2019.1667229
M3 - Article
C2 - 31553250
AN - SCOPUS:85072746435
VL - 17
SP - 689
EP - 698
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
SN - 1478-7210
IS - 9
ER -