Celiac disease and intestinal metaplasia of the esophagus (Barrett's esophagus)

Roberto Maieron, Luca Elli, Marco Marino, Irene Floriani, Francesco Minerva, Claudio Avellini, Giovanni Falconieri, Stefano Pizzolitto, Maurizio Zilli

Research output: Contribution to journalArticle

Abstract

Previous studies on celiac patients demonstrated that exposure to gliadin alters the motility of the upper gastrointestinal tract, leading to increased acid reflux. No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of chronic reflux in adult celiac patients. Our purpose was to evaluate endoscopically and histologically the esophagi of a group of untreated celiac patients. We studied 60 celiac patients, 13 men and 47 women (mean age, 40 ± 14 [SD] years; range, 18-80 years), at their first endoscopy (following a normal diet). The distal esophagus was evaluated and multiple biopsies were taken. Hematoxylin-eosin and alcian blue stainings were performed. A group of nonceliac, age- and sex-matched patients was used as a control. We found intestinal metaplasia in the distal esophagus of 16 of 60 (26.6%) celiacs (mean age, 45 ± 13 years; range, 27-75 years), in comparison with a control-group prevalence of 10.9% (OR, 3.9; 95% CI, 1.4-11.2%). Among the celiac group with metaplasia, only one patient had reflux-like symptoms. None had esophagitis. In conclusion, we observed an increased prevalence of esophageal metaplasia in patients with celiac disease. This finding could be the result of motor abnormalities leading to chronic acid reflux, combined with a mucosa which is sensitive to gliadin.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalDigestive Diseases and Sciences
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Barrett's esophagus
  • Celiac disease
  • Gluten
  • Histology
  • Intestinal metaplasia

ASJC Scopus subject areas

  • Gastroenterology

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    Maieron, R., Elli, L., Marino, M., Floriani, I., Minerva, F., Avellini, C., Falconieri, G., Pizzolitto, S., & Zilli, M. (2005). Celiac disease and intestinal metaplasia of the esophagus (Barrett's esophagus). Digestive Diseases and Sciences, 50(1), 126-129. https://doi.org/10.1007/s10620-005-1289-6