Celiac disease associated with autoimmune myocarditis

Andrea Frustaci, Lucio Cuoco, Cristina Chimenti, Maurizio Pieroni, Giuseppina Fioravanti, Nicola Gentiloni, Attilio Maseri, Giovanni Gasbarrini

Research output: Contribution to journalArticlepeer-review


Background - Both celiac disease (CD) and myocarditis can be associated with systemic autoimmune disorders; however, the coexistence of the 2 entities has never been investigated, although its identification may have a clinical impact. Methods and Results - We screened the serum of 187 consecutive patients with myocarditis (118 males and 69 females, mean age 41.7±14.3 years) for the presence of cardiac autoantibodies, anti-tissue transglutaminase (IgA-tTG), and anti-endomysial antibodies (AEAs). IgA-tTG-positive and AEA-positive patients underwent duodenal endoscopy and biopsy and HLA analysis. Thirteen of the 187 patients were positive for IgA-tTG, and 9 (4.4%) of them were positive for AEA. These 9 patients had iron-deficient anemia and exhibited duodenal endoscopic and histological evidence of CD. CD was observed in 1 (0.3%) of 306 normal controls (P4% of the patients with myocarditis. In these patients, immunosuppression and a gluten-free diet can be effective therapeutic options.

Original languageEnglish
Pages (from-to)2611-2618
Number of pages8
Issue number22
Publication statusPublished - Jun 5 2002


  • Celiac disease
  • Immune system
  • Myocarditis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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