Celiac disease, epilepsy, and occipital calcifications: Histopathological study and clinical outcome

Paolo Tinuper, Giuseppe Plazzi, Federica Provini, Angelina Cerullo, Danielle Gambarelli, Jean Francois Pellissier, Elio Lugaresi

Research output: Contribution to journalArticlepeer-review

Abstract

Bye et al. in 1993 first described the pathological findings in a patient with celiac disease (CD), bilateral occipital calcifications, and drug-resistant epilepsy who became seizure-free after extensive occipital resection. We report a case with all identical anatomoclinical condition in which surgical removal of the circumscribed calcified lesion was ineffective and epilepsy worsened until a gluten-free diet was started. The poor surgical outcome may have been due to residual epileptogenic tissue or to an unidentified secondary epileptic temporal focus. Our observation confirms the histopathological characteristics of the cerebral lesion in CD and the importance of a gluten-free diet in controlling seizures.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalJournal of Epilepsy
Volume9
Issue number3
DOIs
Publication statusPublished - Aug 1996

Keywords

  • Celiac disease
  • Gluten-free diet
  • Occipital calcifications
  • Partial seizures
  • Therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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