Celiac disease in Down's syndrome with HLA serological and molecular studies

P. Failla, C. Ruberto, M. C. Pagano, M. Lombardo, G. Bottaro, B. Perichon, R. Krishnamoorthy, C. Romano, A. Ragusa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The association between Down's syndrome (DS) and celiac disease (CD) has been confirmed by several authors. The sensitivity and specificity of antigliadin antibodies (AGAs), the clinical features of subjects with DS and CD (DS-CD+), the incidence of CD, and the results of serological and molecular class I and II HLA typing were determined in a sample of 57 Sicilian subjects with DS. Six (10.5%) and 17 subjects (29.8%) showed high levels of IgA AGAs and IgG AGAs, respectively. AGAs sensitivity and specificity were lower than in the population without DS. Ten people with DS were submitted to jejunal biopsy, and seven (12.2%) showed CD according to ESPGAN criteria. All seven patients were put on gluten-free diet, followed by rapid disappearance of symptoms. Class I and II HLA serological and molecular typing was carried out in seven DS-CD+ subjects, 22 people with DS without CD (DS-CD-), five subjects with CD without DS, and 20 controls. Between DS-CD+ and DS-CD- subjects, no statistically significant difference regarding serum HLA class I antigens was found. DQA1*0101 allele appears significantly in DS-CD+ patients and deserves to be searched for in a larger sample to assess its meaning in the DS-CD association.

Original languageEnglish
Pages (from-to)303-306
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume23
Issue number3
DOIs
Publication statusPublished - 1996

Fingerprint

Down syndrome
celiac disease
Celiac Disease
Down Syndrome
Histocompatibility Testing
antibodies
Antibodies
gluten-free diet
Gluten-Free Diet
Molecular Typing
Sensitivity and Specificity
Histocompatibility Antigens Class I
Antibody Specificity
HLA Antigens
disease incidence
Immunoglobulin A
signs and symptoms (animals and humans)

Keywords

  • Antigliadin antibodies
  • Celiac disease
  • Down's syndrome
  • HLA antigens

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Celiac disease in Down's syndrome with HLA serological and molecular studies. / Failla, P.; Ruberto, C.; Pagano, M. C.; Lombardo, M.; Bottaro, G.; Perichon, B.; Krishnamoorthy, R.; Romano, C.; Ragusa, A.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 23, No. 3, 1996, p. 303-306.

Research output: Contribution to journalArticle

Failla, P, Ruberto, C, Pagano, MC, Lombardo, M, Bottaro, G, Perichon, B, Krishnamoorthy, R, Romano, C & Ragusa, A 1996, 'Celiac disease in Down's syndrome with HLA serological and molecular studies', Journal of Pediatric Gastroenterology and Nutrition, vol. 23, no. 3, pp. 303-306. https://doi.org/10.1097/00005176-199610000-00016
Failla, P. ; Ruberto, C. ; Pagano, M. C. ; Lombardo, M. ; Bottaro, G. ; Perichon, B. ; Krishnamoorthy, R. ; Romano, C. ; Ragusa, A. / Celiac disease in Down's syndrome with HLA serological and molecular studies. In: Journal of Pediatric Gastroenterology and Nutrition. 1996 ; Vol. 23, No. 3. pp. 303-306.
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