Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

Ugo Cavallaro, Gerhard Christofori

Research output: Contribution to journalArticlepeer-review


In addition to their adhesive functions, cell-adhesion molecules modulate signal-transduction pathways by interacting with molecules such as receptor tyrosine kinases, components of the WNT signalling pathway and RHO-family GTPases. So, changes in the expression of cell-adhesion molecules affect not only the adhesive repertoire of a cell, but also its signal-transduction status. Conversely, signalling pathways can modulate the function of cell-adhesion molecules, altering the interactions between cells and their environment. Recent experimental evidence indicates that such processes have a crucial role in tumour progression, in particular during invasion and metastasis.

Original languageEnglish
Pages (from-to)118-132
Number of pages15
JournalNature Reviews Cancer
Issue number2
Publication statusPublished - Feb 2004

ASJC Scopus subject areas

  • Cancer Research


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