Cell based approaches for myocardial regeneration and artificial myocardium

Jorge Genovese, Miguel Cortes-Morichetti, Emmanuel Chachques, Giacomo Frati, Amit Patel, Juan C. Chachques

Research output: Contribution to journalArticle

Abstract

Ischemic myocardial disease, the main cause of heart failure, is a major public health and economic problem. Given the aging population, heart failure is becoming an increasing clinical issue and a substantial financial burden. Thus, research in heart failure is of relevant interest and importance, involving specialties such as cellular and molecular biology, tissue engineering, genetics, biophysics and electrophysiology. Stem cell-based regenerative therapy is undergoing experimental and clinical trials in order to limit the consequences of decreased contractile function and compliance of damaged ventricles following myocardial infarction or in patients presenting non-ischemic dilated cardiomyopathies. This biological approach is particularly attractive due to the potential for myocardial regeneration with a variety of myogenic and angiogenic cell types. The development of a bio-artificial myocardium using biological or synthetic matrix is a new challenge.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalCurrent Stem Cell Research and Therapy
Volume2
Issue number2
DOIs
Publication statusPublished - May 2007

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Keywords

  • Artificial myocardium
  • Cardiomyopathy
  • Cellular cardiomyoplasty
  • Heart failure
  • Ischemic heart disease
  • Stem cell transplantation
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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