Cell based therapy for duchenne muscular dystrophy

Andrea Farini, Paola Razini, Silvia Erratico, Yvan Torrente, Mirella Meregalli

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Mutations in the dystrophin gene cause an X-linked genetic disorder: Duchenne muscular dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small number of cells are required to obtain a therapeutic effect. Here, we discussed about multiple types of myogenic stem cells and their possible use to treat DMD. The identification of a stem cell population providing efficient muscle regeneration is critical for the progression of cell therapy for DMD. We speculated that the most promising possibility for the treatment of DMD is a combination of different approaches, such as gene and stem cell therapy.

Original languageEnglish
Pages (from-to)526-534
Number of pages9
JournalJournal of Cellular Physiology
Volume221
Issue number3
DOIs
Publication statusPublished - Dec 2009

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Duchenne Muscular Dystrophy
Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Genes
Dystrophin
X-Linked Genes
Inborn Genetic Diseases
Muscle
Therapeutic Uses
Cells
Regeneration
Cell Count
Muscles
Mutation
Population

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Cell based therapy for duchenne muscular dystrophy. / Farini, Andrea; Razini, Paola; Erratico, Silvia; Torrente, Yvan; Meregalli, Mirella.

In: Journal of Cellular Physiology, Vol. 221, No. 3, 12.2009, p. 526-534.

Research output: Contribution to journalArticle

Farini, Andrea ; Razini, Paola ; Erratico, Silvia ; Torrente, Yvan ; Meregalli, Mirella. / Cell based therapy for duchenne muscular dystrophy. In: Journal of Cellular Physiology. 2009 ; Vol. 221, No. 3. pp. 526-534.
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