Cell-based Therapy for Perianal Fistulising Crohn's Disease

Paulo Gustavo Kotze, Antonino Spinelli, Amy Lee Lightner

Research output: Contribution to journalReview article

Abstract

BACKGROUND: The management of complex perianal fistulas in Crohn's disease (CD) represents a challenge for patients, gastroenterologists and colorectal surgeons. There are clear limitations with current medical and surgical options, and healing rates remain far from what is expected. A multidisciplinary approach with optimized medical therapy, usually anti-TNF agents, associated with setons and additional surgical techniques is currently the best strategy to aim fistula healing.

METHODS: A comprehensive review of the literature was conducted on the use of mesenchymal stem cells (MSCs).

RESULTS: The use of mesenchymal stem cells (MSCs) has recently emerged as a promising new therapeutic strategy for complex fistulas in CD patients. This review summarizes the evidence of the use of MSCs in complex CD fistulas, by exploring in detail the types of cells that can be used and their modes of delivery. Additionally, the results of the most recent phase III randomized trial with local MSCs injection are described, and future challenges of this therapeutic option are discussed.

CONCLUSION: The use of MSCs represents hope for better outcomes in patients with CD-related perianal fistulas. More research in the field will help to position this specific therapy in treatment algorithms.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalCurrent Pharmaceutical Design
Volume25
Issue number1
DOIs
Publication statusPublished - 2019

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Keywords

  • Crohn Disease/therapy
  • Humans
  • Mesenchymal Stem Cell Transplantation
  • Rectal Fistula/therapy
  • Treatment Outcome

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