Abstract
Recent advances in cell biology provides evidence that adipose tissue cells, adipocytes and stromal fibroblasts, are bona fide secretory cells. That is, using endopara- and autocrine pathways, these cells synthesize and release a number of multi-functional molecules, including cytokines, growth factors, enzymes, and hormones. These are collectively named adipokines. To tackle the issue of pathobiology and therapy of adipokine-related diseases a sound knowledge of the cell biology and pharmacology of adipose tissue secretion is required. An update of this matter is reviewed here. Perspectives for studying roles of locally produced adipokines in the disease process affecting the associated organ are also presented. We term this the adipose tissue-directed (adipotopic) approach in the study of pathobiology, prevention, and therapy of disease.
| Original language | English |
|---|---|
| Pages (from-to) | 181-191 |
| Number of pages | 11 |
| Journal | Fabad Journal of Pharmaceutical Sciences |
| Volume | 25 |
| Issue number | 4 |
| Publication status | Published - 2000 |
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Keywords
- Adipocytes
- Adipokines
- Adipose tissue
- Disease
- Fibroblasts
- Pharmacology
- Secretion
- Therapy
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Cell biology and pharmacology of adipose tissue secretion. / Chaldakov, G. N.; Fiore, M.; Hristova, M.; Aloe, L.
In: Fabad Journal of Pharmaceutical Sciences, Vol. 25, No. 4, 2000, p. 181-191.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell biology and pharmacology of adipose tissue secretion
AU - Chaldakov, G. N.
AU - Fiore, M.
AU - Hristova, M.
AU - Aloe, L.
PY - 2000
Y1 - 2000
N2 - Recent advances in cell biology provides evidence that adipose tissue cells, adipocytes and stromal fibroblasts, are bona fide secretory cells. That is, using endopara- and autocrine pathways, these cells synthesize and release a number of multi-functional molecules, including cytokines, growth factors, enzymes, and hormones. These are collectively named adipokines. To tackle the issue of pathobiology and therapy of adipokine-related diseases a sound knowledge of the cell biology and pharmacology of adipose tissue secretion is required. An update of this matter is reviewed here. Perspectives for studying roles of locally produced adipokines in the disease process affecting the associated organ are also presented. We term this the adipose tissue-directed (adipotopic) approach in the study of pathobiology, prevention, and therapy of disease.
AB - Recent advances in cell biology provides evidence that adipose tissue cells, adipocytes and stromal fibroblasts, are bona fide secretory cells. That is, using endopara- and autocrine pathways, these cells synthesize and release a number of multi-functional molecules, including cytokines, growth factors, enzymes, and hormones. These are collectively named adipokines. To tackle the issue of pathobiology and therapy of adipokine-related diseases a sound knowledge of the cell biology and pharmacology of adipose tissue secretion is required. An update of this matter is reviewed here. Perspectives for studying roles of locally produced adipokines in the disease process affecting the associated organ are also presented. We term this the adipose tissue-directed (adipotopic) approach in the study of pathobiology, prevention, and therapy of disease.
KW - Adipocytes
KW - Adipokines
KW - Adipose tissue
KW - Disease
KW - Fibroblasts
KW - Pharmacology
KW - Secretion
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=0034465245&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034465245&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0034465245
VL - 25
SP - 181
EP - 191
JO - Fabad Journal of Pharmaceutical Sciences
JF - Fabad Journal of Pharmaceutical Sciences
SN - 1300-4182
IS - 4
ER -