Cell biology and pharmacology of adipose tissue secretion

G. N. Chaldakov, M. Fiore, M. Hristova, L. Aloe

Research output: Contribution to journalArticle

Abstract

Recent advances in cell biology provides evidence that adipose tissue cells, adipocytes and stromal fibroblasts, are bona fide secretory cells. That is, using endopara- and autocrine pathways, these cells synthesize and release a number of multi-functional molecules, including cytokines, growth factors, enzymes, and hormones. These are collectively named adipokines. To tackle the issue of pathobiology and therapy of adipokine-related diseases a sound knowledge of the cell biology and pharmacology of adipose tissue secretion is required. An update of this matter is reviewed here. Perspectives for studying roles of locally produced adipokines in the disease process affecting the associated organ are also presented. We term this the adipose tissue-directed (adipotopic) approach in the study of pathobiology, prevention, and therapy of disease.

Original languageEnglish
Pages (from-to)181-191
Number of pages11
JournalFabad Journal of Pharmaceutical Sciences
Volume25
Issue number4
Publication statusPublished - 2000

Keywords

  • Adipocytes
  • Adipokines
  • Adipose tissue
  • Disease
  • Fibroblasts
  • Pharmacology
  • Secretion
  • Therapy

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Chaldakov, G. N., Fiore, M., Hristova, M., & Aloe, L. (2000). Cell biology and pharmacology of adipose tissue secretion. Fabad Journal of Pharmaceutical Sciences, 25(4), 181-191.