Cell death pathology: Cross-talk with autophagy and its clinical implications

Ivano Amelio, Gerry Melino, Richard A. Knight

Research output: Contribution to journalArticle

Abstract

Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, " autophagic cell death" Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume414
Issue number2
DOIs
Publication statusPublished - Oct 22 2011

Keywords

  • Apoptosis
  • Autophagy
  • Cancer
  • P53
  • Programmed cell death

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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