Cell death protection by 3-aminobenzamide: Impairment of cytoskeleton function in human NK cell-mediated killing

W. Malorni, G. Rainaldi, E. Straface, R. Rivabene, A. Cossarizza, S. Salvioli, D. Monti, C. Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

3-aminobenzamide, an inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase, is capable of interfering with the tumor cell lysis induced by specialized cells from the immune system, i.e., natural killer (NK) cells. In this report we suggest that the mechanism by which the drug can exert its protective effects on target cell killing by NK effectors can also be due to its ability to impaire cell-to-cell conjugate formation (binding), without affecting either the expression of cell adhesion molecules nor the features of effector-target cell contact. The mechanism of this inhibition seems to be associated with an alteration of cytoskeletal elements involved during conjugate formation, i.e., with the integrity and function of the microfilament system.

Original languageEnglish
Pages (from-to)1250-1255
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume199
Issue number3
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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