Cell death: Tipping the balance of autoimmunity and tissue repair

Patrizia Rovere-Querini, Silvia Brunelli, Emilio Clementi, Angelo A. Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation is a key homeostatic process elicited by microbial components and by tissue damage. Increasing evidence indicates that the outcomes either tissue repair or persistent inflammatory damage and degeneration tightly depend on the pattern of cell death in situ and on infiltrating leukocytes and antigen presenting cells. Defects in the initiation andexecution steps of programmed cell death such as in the clearance of cell debris are indeed often associated to inflammation defective repair and autoinummity. Here we report recent developments on the control of apoptosis induction and execution discussing how cell death may be exploited for therapeutic purposes and the links between cell death persisting inflammation and stem cell recruitment and activation in experimental models of complex human diseases such as muscular dystrophy and cancer.

Original languageEnglish
Pages (from-to)269-277
Number of pages9
JournalCurrent Pharmaceutical Design
Volume14
Issue number3
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Autoimmunity
  • Cyclic GMP
  • DAMPS/Alarmins
  • Mesoangioblasts
  • Musculae dystrophy
  • Nitric oxide
  • Sphingolipids
  • Stem cells
  • Tumours

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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