Cell discohesion and multifocality of carcinoma in situ of the bladder: New insight from the adhesion molecule profile (e-Cadherin, Ep-CAM, and MUC1)

Carlo Patriarca, Piergiuseppe Colombo, Angelo Pio Taronna, Jelle Wesseling, Giada Franchi, Francesca Guddo, Richard Naspro, Roberto Maria MacChi, Paolo Giunta, Marcello Di Pasquale, Michele Parente, Carmelo Arizzi, Massimo Roncalli, Biagio Campo

Research output: Contribution to journalArticle

Abstract

Urothelial cell carcinoma in situ (CIS) of the bladder is a superficially diffusive and highly discohesive disease. The authors analyzed the expression of some adhesion molecules (e-cadherin and Ep-CAM) and MUC1 in 32 unifocal and multifocal bladder urothelial cell CIS in an attempt to clarify this discohesion. E-cadherin was strongly expressed, in more than 75% of the cases. The presence of methylation of the CDH1 e-cadherin promoter gene was also investigated, but methylation was found in only one case. Ep-CAM was present in all the cases with a heterogeneous staining pattern. Similarly, MUC1/episialin was variously present in 94% of the cases without a polarized staining pattern and was expressed more strongly in cases with multifocal disease. Because loss of MUC1 polarization leads to interference with cell-cell adhesion mechanisms mediated by cadherins, these findings help explain why bladder urothelial cell CIS often shows a discohesive morphology and multifocality despite a strongly expressed adhesion molecule profile. Finally, Ep-CAM expression might provide some support for future target therapy trials.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalInternational Journal of Surgical Pathology
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 2009

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Keywords

  • Bladder
  • Carcinoma in situ (CIS)
  • Discohesion
  • E-cadherin
  • MUC1
  • Urothelial cell carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Patriarca, C., Colombo, P., Pio Taronna, A., Wesseling, J., Franchi, G., Guddo, F., Naspro, R., MacChi, R. M., Giunta, P., Di Pasquale, M., Parente, M., Arizzi, C., Roncalli, M., & Campo, B. (2009). Cell discohesion and multifocality of carcinoma in situ of the bladder: New insight from the adhesion molecule profile (e-Cadherin, Ep-CAM, and MUC1). International Journal of Surgical Pathology, 17(2), 99-106. https://doi.org/10.1177/1066896908326918