Cell-free DNA as a diagnostic marker for cancer: Current insights

Research output: Contribution to journalReview articlepeer-review


The increasing knowledge of the molecular pathogenesis of cancer and the rapid development of new molecular techniques are promoting the study of early molecular alterations involved in cancer development in body fluids. Specific genetic and epigenetic alterations could be found in plasma, serum, and urine cell-free DNA (cfDNA) and could potentially be used as diagnostic biomarkers for several types of cancers. This review focuses on the role of cfDNA in diagnosis: a PubMed search was performed by selecting papers according to journal impact factor and robustness of statistical analysis. A comprehensive evaluation of “liquid biopsy”, including cfDNA analysis, will be one of the critical challenges to better understand the early mechanisms of cancer development.

Original languageEnglish
Pages (from-to)6549-6559
Number of pages11
JournalOncoTargets and Therapy
Publication statusPublished - Oct 25 2016


  • Cancer
  • Cell-free DNA
  • Diagnosis
  • Liquid biopsy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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